摘要
目的:系统评价护肝片与其它方案治疗脂肪性肝病疗效的差异。方法:系统检索中国学术文献总库(CNKI)、维普中文科技期刊数据库、万方数字化期刊库、中国生物医学文献数据库(CBM)、Pub Med、The Cochrane Library及Cochrane对照试验注册资料库,根据纳入与排除标准筛选文献,评价文献质量。两人独立提取研究资料,交叉检查所得资料,采用Cochrane协作网提供的软件Review Manager 5.2软件进行研究资料的统计分析。结果:纳入6篇随机对照试验,共治疗370例脂肪性肝病患者。有效率研究之间无明显异质(χ2=3.17,df=5,P=0.67>0.1),有效率的OR=0.20和95%的CI为[0.11,0.35],试验组护肝片与对照组常规方案在疗效方面有显著性差异(P<0.000 01)。结论:护肝片与常规方案相比,护肝片治疗脂肪性肝病的疗效更为确切,而且副作用小,能指导临床医生用药。
Objective ： To review the efficacy of Hugan Tablet in the treatment of fatty liver disease. Methods ： Retrieving papers from China national knowledge infrastructure （ CNKI ）, Weipu database （ VIP ）, China biology medicine （ CBM ）, Wanfang Data, Pubmed and cochrane central register of controved trials （ CENTRAL ） .Two reviewers independently perused the papers retrieved, screened out the unaceepted ones according to the inclusion and exclusion criteria and had their outcomes cross-checked and evaluate the quality of them. Software Review Manager 5.2 was used for analysis. Results ： A total of 6 studies including 370 fatty liver disease patients. The merged data shows Hugan Tablet had a higher effective rate in treating fatty liver disease, and there is no significant heterogeneity between Hugan Tablet group and control group （ X 2=3-17, dr-5, P=0.67〉0.1 ）, OR=0.20195% CI （0.11,0.35 ）].Meta-analysis results show that clinical efficacy of Hugan Tablet was better than that of the control group in the treatment of fatty liver disease and there was a significant difference （ P〈0.000 01 ） .Conclusion ： Hugan Tablet had better efficacy in the treatment of fatty liver disease than other conventional therapy with fewer adverse effects, which may guide the clinical treatment for the doctors.
出处
《辽宁中医药大学学报》
CAS
2015年第6期164-166,共3页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
护肝片
脂肪性肝病
META分析
随机对照试验
Hugan Tablet
fatty liver disease
meta analysis
randomized control trials
