摘要
目的:对羌独祛湿止痛汤联合来氟米特对类风湿性关节炎的临床疗效进行探讨。方法:将90例类风湿性关节炎患者随机分为对照组和观察组,每组各45例。对照组给予口服来氟米特,20 mg/d,观察组在此基础上加以中药汤剂羌独祛湿止痛汤,每日1剂。治疗3个月后观察其血液指标、中医证候积分变化,并据此对两组的临床疗效进行比较分析。结果:治疗后与对照组相比,观察组血沉(ESR)、类风湿因子(RF)、C-反应蛋白(CRP)水平及中医证候积分均明显降低,主要症状体征改善率显著提高,且临床疗效也明显优于对照组,差异均具有统计学意义(P<0.05)。在不良反应方面,观察组发生率相比对照组有所降低,但差异并不具有统计学意义(P>0.05)。结论:羌独祛湿止痛汤联合来氟米特治疗可有效改善患者的临床症状,提高临床疗效,对控制患者不良反应也有着积极的作用。
Objective： To discuss the clinical effect of Qiangdu Qushi Zhitong Soup combined with leflunomide for 90 cases of patients with rheumatoid arthritis. Methods ： 90 cases of patients with rheumatoid arthritis were randomly divided into control group and observation group, each group was 45 cases. The patients of control group were given ora leflunomidel, 20 mg/d, the patients of observation group were traditional Chinese medicine by Qiangdu Qushi Zhitong soup on the basis of control group, one dose a day. To observe the blood indexes, the main symptoms and signs and traditional Chinese medicine symptom integral after treatment of 3 months, and c＇omparative analysis the clinical curative effect of two groups.Results ： Compared with control group after treatment, the level of ESR, RF, CRP of the observation group were significantly lower, and traditional Chinese medicine symptom integral was significantly improve, and the main symptoms and signs and clinical curative effect were obviously better than that of control group, the differences were statistically significant （ P〈0.05 ）. In terms of adverse reactions, the incidence of observation group was decreased than that of the control group, but the difference was not statistically significant （ P〉0.05 ）. Conclusion ： Qiangdu Qushi Zhitong Soup combined with leflunomide can effectively improve the patient＇s clinical symptoms and the clinical curative effect, and has a positive role to control the adverse reactio.
出处
《辽宁中医药大学学报》
CAS
2015年第6期174-176,共3页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
类风湿性关节炎
来氟米特
中药
rheumatoid arthritis
leflunomide
traditional Chinese medicine
