摘要
背景:在临床治疗过程中使用的输尿管多为硅胶或聚氨酯高分子材料制造,由于此类材料在人体内不能够自行降解并被人体吸收,所以研制新型可生物降解双J输尿管支架管成为目前研究的重点。目的:总结不同类型双J输尿管支架管的临床应用和研制方向。方法:应用计算机检索万方数据库、中国知网和Pub Med文献数据库2010至2015年的文献,检索关键词为"双J输尿管,支架管,临床;Double-J ureteral,Stent,Clinical"。结果与结论:传统的双J输尿管支架有人工多聚物支架和金属支架,此两种输尿管支架生物相容性差,容易引起多种并发症。随着对输尿管支架研究的不断深入,可生物降解输尿管支架逐渐被研发,其具有良好力学性能、生物惰性和体内降解性,置入人体后在不影响上尿路动力学的情况下可确保尿液引流;支架的组织相容性好,组织间反应小,吸收后消失;局部输尿管支架避免了对输尿管膀胱连接处抗返流功能的影响;在完成内引流和支撑作用后可自行降解并随尿液排出体外,避免了2次使用膀胱镜取出支架的问题,同时也避免了泌尿系感染、肾功能损害等并发症。
BACKGROUND： Ureteral stents used in clinical treatment are mostly made of silicone or polyurethane polymer materials, but these materials cannot be degraded and absorbed in the human body. Therefore, to develop a new type of double-J biodegradable ureteral stent has become a research focus. OBJECTIVE： To summarize the clinical application and development of different kinds of double-J ureteral stents. METHODS： Related＇literatures were retrieved from Wanfang, CNKI and PubMed databases using the keywords of ＂double-J ureteral, stent, clinical＂ in Chinese and English, respectively. The retrieval time ranged from 2010 to 2015. RESULTS AND CONCLUSION： Traditional double-J Ureteral stents can be divided into polymer stents and metal stents, both of which have poor biocompatibility and easily cause various complications. With the in-depth studies of ureeterel stents, biodegradable ureteral stents have been developed, which have good mechanical properties, biological inertness and in vivo degradation that can ensure drainage of urine after implantation in the human body without affecting the dynamics of the upper urinary tract; have good histocompatibility, little reactions between tissues, and can disappear after absorption; can avoid the impact on the anti-reflux function at the junction between the ureter and urinary bladder; and can be degraded and excreted via the urine after completion of drainage and support to avoid the secondary use of cystoscopy, and also to avoid urinary tract infections, renal dysfunction and other complications.
出处
《中国组织工程研究》
CAS
北大核心
2015年第16期2603-2607,共5页
Chinese Journal of Tissue Engineering Research
基金
张家口市第二医院外科
