摘要
目的:了解我院抗菌药物致不良反应(ADR)发生的规律及特点,为临床安全、合理用药提供参考。方法:对我院2011年1月-2014年6月上报国家ADR监测中心的121例抗菌药物致ADR报告,按患者年龄、性别、涉及的药品种类、给药途径、累及器官/系统及临床表现等方面进行回顾性分析。结果:121例抗菌药物致ADR报告中,≥61岁患者发生ADR最多,占23.14%;静脉滴注是引发ADR的主要途径,占80.99%;涉及10类抗菌药物,共26种药,以头孢菌素类居多(占53.72%),其次为青霉素类(占11.57%);ADR累及器官/系统以皮肤及其附件损害为主,占47.37%。结论:临床使用抗菌药物应充分考虑患者的年龄及自身状况,结合皮试和药敏试验,加强ADR监测等,是减少ADR发生的有效途径。
OBJECTIVE： To study the incidence and characteristics of adverse drug reactions （ADR） induced by antibiotics and provide reference for the clinical rational use of drug. METHODS： 121 ADR reports reduced by antibiotics in our hospital from Jan. 2011 to Jun. 2014 were retrospectively analyzed in aspects of age, gender, drug types, route of administration, organs or sys- tems involved in ADR and clinical manifestations, etc. RESULTS： Among 121 cases of ADR reports, the incidence of ADR in the age group above 61 occupied the highest percentage, accounting for 23.14% ; intravenous infusion was the main way leading to ADR, accounting for 80.99%; there were 10 types of antibiotics including 26 drugs involved, mainly cephalosporins （53.72%）, followed by penicillins （11.57%）, the ADR might appeared within the first 30 rain so that it needed to strengthen the medication monitoring within the time; lesions of skin and its appendants were the main organs or systems involved in ADR, accounting for 47.37%. CONCLUSIONS： The way to reduce ADR is to consider age and condition of patients completely skin test and drug sensi- tive test, strengthen the ADR monitoring of antibiotics.
出处
《中国药房》
CAS
北大核心
2015年第17期2361-2363,共3页
China Pharmacy
关键词
药品不良反应
合理用药
用药监测
抗菌药物
Adverse drug reaction
Rational drug use
Monitoring of drug use
Antibacterials
