摘要
目的回顾性分析精神分裂症患者血清C反应蛋白(C-reactive protein,CRP)的水平和阳性率以及CRP阳性和阴性的精神分裂症患者精神病性症状严重程度及住院时长的差异。方法选取广州市脑科医院符合《国际疾病分类(第10版)》(ICD-10)诊断标准的精神分裂症住院患者90例,对其入院后1周内血清CRP水平进行回顾分析,以CRP>10mg/L为界,将患者划分为CRP阳性组和阴性组。采用阳性与阴性症状量表(PANSS)评定入院1周内及出院前1周精神症状的严重程度。结果 90例精神分裂症患者中,入院时CRP阳性患者15例(16.7%),血清CRP平均浓度为(26.8±11.8)mg/L;CRP阴性患者75例(83.3%),平均浓度为(4.8±1.7)mg/L。入院时两组患者PANSS阳性、阴性、一般病理学分量表评分及PANSS总评分差异无统计学意义(P>0.05)。两组患者出院时PANSS分量表评分及总评分差异无统计学意义(P>0.05),但CRP阳性患者住院时间长于CRP阴性患者,差异有统计学意义(P<0.05)。结论血清CRP水平在部分精神分裂症患者中较高,CRP水平与精神症状严重程度没有相关性。CRP阳性患者住院时间长于CRP阴性者,炎症反应的存在可能会影响住院时间。
Objective The serum C-reactive protein( CRP)level in schizophrenia patients and the association ketween serum level of CRP and the severity of psychiatric symptoms and hospitalization duration were retrospectively analyzed. Methods 90 schizo=phrenia patients in Guangzhou Brain Hospital who met the diagnostic criteria of ICD-10 were included. The data of the serum CRP level within the first weed of hospitalization was analyzed. Using CRP﹥10mg /L as a cutoff value to classify the patients into CRP posi=tive and CRP negative group. Positive and negative symptom scale( PANSS)was applied to evaluate the severity of psychiatric symp=toms within the first weed of hospitalization and one weed kefore discharge. Results CRP serum level in 16. 7% schizophrenia patients was higher than normal value. There were 15(16. 7%)patients in CRP positive group. The serum CRP value was(26. 8 ± 11. 8)mg/L. 75(83. 3%)patients in CRP positive group the serum CRP value was(4. 8 ± 1. 7)mg/L. There were no significant difference ketween CRP positive and CRP negative group on PANSS sukscale and total scores evaluated one weed within hospitalization and one weed ke=fore discharge. The hospitalization duration of CRP positive group was significantly longer than CRP negative group. Conclusion Serum CRP level was increased in part of schizophrenia patients kut wasnˊt associated with the severity of psychiatric symptoms. The in=flammatory response may influence the hospitalization duration.
出处
《四川精神卫生》
2015年第3期208-211,共4页
Sichuan Mental Health
基金
国家精神科临床重点专科建设项目子项目(201202-001
201201001)
广州市医药卫生科技基金(20131A011091)
广州市医学重点学科建设子项目(GBH2014-ZD03)
关键词
精神分裂症
C反应蛋白
精神症状
住院时长
Schizophrenia
C-reactive protein
Psychiatric symptoms
Hospitalization duration
