摘要
目的:检测甲状腺乳头状癌组织中EphA2与E-cadherin蛋白的表达及其临床意义,探究两者的相关性。方法:采用免疫组织化学SP/PV方法检测43例甲状腺乳头状癌、11例甲状腺腺瘤、10例癌旁正常甲状腺组织中蛋白EphA2与E-cadherin表达,并观察其与临床病理因素的关系。结果:EphA2蛋白在甲状腺乳头状癌中的表达(阳性率58.14%)分别高于甲状腺腺瘤(阳性率18.18%)和正常甲状腺组织(阳性率10.00%)的表达(P<0.05),而E-cadherin蛋白在甲状腺乳头状癌(阳性率32.56%)中的表达分别低于甲状腺腺瘤(阳性率81.81%)及正常甲状腺组织(阳性率100.00%)的表达(P<0.05),甲状腺乳头状癌中蛋白EphA2与E-cadherin的表达与患者的淋巴结转移和临床分期相关(P<0.05),而与患者的性别、年龄及肿瘤的大小均无关(P>0.05),且EphA2与E-cadherin蛋白在甲状腺乳头状癌中的表达呈负相关(r=-0.416,P<0.01)。结论:甲状腺乳头状癌的发生发展与EphA2和E-cadherin蛋白的表达密切相关。
Objective To investigate the expression and clinical significance of EphA2 and E cadherin proteins in papillary thyroid carcinoma tissues, and to explore the relationship between them. Method：Using immunohisto- chemical SP/PV method, we detected the expression of EphA2 and E cadherin in tumors of 43 papillary thyroid carcinomas, 11 thyroid adenoma and 10 normal thyroid tissues, then studied their relationships with clinic patho- logical factors. Result：The total positive rates of EphA2 and E cadherin expression were 58.14% and 32.56% in papillary thyroid carcinoma tissues, 18.18% and 81.81% in thyroid adenorna tissues and they were 10.00% and 100.00% in normal thyroid tissues respectively. The positive expression of EphA2 in carcinoma tissues was higher than in the thyroid adenoma tissues and normal thyroid tissues （P〈0.05） and the positive expression of E cadher in in carcinoma tissues was lower than that in the thyroid adenoma tissues and normal thyroid tissues （P〈0.05）. The positive expression of EphA2 and E cadherin was associated with lymph node metastasis and histological grade （P〈0.05）, but it was not associated with all the clinic-pathological factors including age, sex and the tumor size （P〉0.05）. In papillary thyroid carcinoma tissues, the expression of EphA2 was negatively correlated with the expression of E cadherin protein （r=-0. 416, P〈0.01）. Conclusion： EphA2 and E cadherin may be involved in carcinogenesis and development of papillary thyroid carcinoma.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2015年第11期1020-1023,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
