摘要
目的研究甲状腺功能亢进(甲亢)患者心率变异性及QT间期离散度(QTd)的变化。方法 52例甲亢患者为甲亢组,49例健康体检者为对照组,对其24 h动态心电图以及常规标准12导联心电图进行回顾性分析,分析比较两组患者的最小心率、最大心率、平均心率值;心率变异性时域指标全部窦性心搏RR间期(简称NN间期)的标准差(SDNN)、RR间期平均值标准差(SDANN)、相邻NN之差>50 ms的个数占总窦性心搏个数的百分比(PNN50)、相邻RR间期差值的均方根(RMSSD)以及最大QT间期(QTmax)、最小QT间期(QTmin)、QT间期离散度(QTmax-QTmin)。结果甲亢组患者的最小心率、最大心率、平均心率均较对照组增高,差异具有统计学意义(P<0.05);SDNN、PNN50、SDANN、RMSSD均较对照组降低,差异具有统计学意义(P<0.05);QTd较对照组增大,差异具有统计学意义(P<0.05)。结论甲亢患者心率变异性及QT离散度异常率较高,自主神经对心脏的调节能力降低,易发生恶性心律失常及心源性猝死,临床上应对该类患者给予高度重视,减少猝死的发生。
Objective To research the changes of heart rate variability and QT interval dispersion （QTd） in hyperthyroidism patients. Methods There were 52 hyperthyroidism patients as hyperthyroidism group and 49 healthy people as control group. A retrospective analysis was made on their 24 h dynamic electrocardiogram and conventional standard 12-lead electrocardiogram. Minimum heart rate, maximum heart rate, and average heart rate values, standard deviation in all sinus cardiac RR interphase （NN interval） （SDNN） in heart rate variability, standard deviation average in RR interphase （SDANN）, proportion of adjacent NN difference 〉50 ms in total number of sinus heart beat （PNN50）, adjacent RR interphase root-mean-square （RMSSD）, maximum QT interval （QTmax）, minimum QT interval （QTmin）, QT interval dispersion （QTmax-QTmin） were analyzed and compared in the two groups. Results The hyperthyroidism group had higher minimum heart rate, maximum heart rate, and average heart rate than the control group, and their difference had statistical significance （P〈0.05）. Its SDNN, PNN50, SDANN, and RMSSD were all lower than the control group, and their difference had statistical significance （P〈0.05）. Its QTd was higher than the control group, and their difference had statistical significance （P〈0.05）. Conclusion Abnormality rates of heart rate variability and QT interval dispersion are high in hyperthyroidism patients, and their regulation function by autonomic nerve for heart is decreased. They are easy to have severe arrhythmia and sudden cardiac death. These patients require high clinical attention, in order to reduce incidence of sudden death.
出处
《中国现代药物应用》
2015年第13期26-28,共3页
Chinese Journal of Modern Drug Application
