摘要
目的探讨GnRH-a辅助下腹腔镜双侧卵巢子宫内膜异位囊肿剔除术的临床疗效及对再妊娠的影响。方法随机选取双侧卵巢子宫内膜异位囊肿患者64例,随机分为干预组34例和常规组30例,干预组给予GnRH-a 3.75 mg注射治疗2 w,随后再行腹腔镜下子宫内膜异位囊肿剔除术;常规组不给予任何预处理直接行腹腔镜手术治疗,比较两组治疗后性激素水平、卵巢直径的变化,随访1年,比较再妊娠情况和囊肿复发情况。结果干预组患者FSH水平为(8.03±2.11)m IU/m L,明显低于常规组,而E2和LH水平均高于常规组,差异具有统计学意义(P<0.05);常规组卵巢直径≤2 cm占67.65%,卵巢体积明显缩小,随访1年,干预组囊肿复发率为5.88%,再妊娠率为63.63%,且术后妊娠间隔间隔时间缩短,与对照组比较差异具有统计学意义(P<0.05)。结论腹腔镜双侧卵巢子宫内膜异位囊肿剔除术术前应用GnRH-a治疗可有效减轻对卵巢储备功能的影响,对有生育要求的患者尽可能有效地保护了卵巢功能。
Objective To investigate the curative effects of GnRH - a assisted laparoscopic resection for bilateral ovarian endometriosis cyst and its influence on the second pregnancy. Methods 64 cases of bilateral ovarian endometriosis cyst were randomly selected and divided into the intervention group （ n = 34） and the conventional group （ n = 30）. The intervention group was given GnRH - a 3.75 mg injection for 2 weeks, then underwent laparoscopic excision for endometriosis cyst, while the conventional group was not given any pretreatment and simply given laparoscopic surgical treatment, then the change of hormone levels and ovarian diameters were compared between the two groups after treatment, and both group received the follow - up for 1 year, then the pregnancy and cyst recurrence were compared. Results The FSH level of the intervention group were （8.03 ±2. 11 ） mIU/mL, significantly lower than the conventional group, while the E2 and LH levels were higher than conventional group with significant difference （P 〈 0. 05）, normal ovary diameter less than 2 cm accounted for 67.65 %, and ovarian volume was significantly reduced; after 1 year of follow -up, the cyst recurrence rate of the intervention group was 5.88%, pregnancy rate was 63.63%, and the postoperative pregnancy interval interval time was shortened with statistically significant difference compared with the conventional group （ P 〈 0. 05 ）. Conclusion Application of GnRH - a before laparoscopic bilateral ovarian endometriosis cyst surgery can effectively reduce the influence on the ovarian reserve function as much as possible and effectively protect the ovarian function for the patients who have the reproduction requirements.
出处
《辽宁医学院学报》
CAS
2015年第3期39-41,共3页
Journal of Liaoning Medical University (LNMU) Bimonthly
