摘要
目的探讨儿童慢性咳嗽与肺炎支原体感染的关系以及大环内酯类抗生素的治疗效果,提高临床诊断及治疗。方法选取2011年7月—2013年7月在蚌埠医学院第二附属医院儿科确诊的92例慢性咳嗽的患儿（为研究组）和104例急性上呼吸道感染患儿（为对照组）,2组患儿均采用被动凝集法进行血清肺炎支原体抗体（MP-Ig M）测定,并采用χ2检验进行组间比较;同时对研究组38例肺炎支原体感染的慢性咳嗽患儿的临床资料进行分析,并给予大环内酯类抗生素序贯治疗以观察疗效。结果研究组肺炎支原体感染38例（占41.3%,38/92）,对照组肺炎支原体感染13例（占12.5%,13/104）,2组比较差异有统计学意义（χ^2=21.04,P〈0.01）;肺炎支原体感染的慢性咳嗽患儿以刺激性干咳多见,76.3%（29/38）的病例外周血白细胞在（4-10）×10^9/L之间,71.1%（27/38）的病例CRP〈10 mg/L,63.2%（24/38）的患儿双肺有不同程度的改变;研究组肺炎支原体感染者应用大环内酯类抗生素序贯治疗后有效率为92.1%,临床治疗效果较好。结论儿童慢性咳嗽与肺炎支原体感染关系密切,大环内酯类抗生素可作为有效的治疗手段。
Objective To investigate the relationship between chronic cough in children and Mycoplasma pneumoniae infection,and therapeutic efficacy of macrolide antibiotics on chronic coughin order to improve the clinical diagnosis and treatment. Methods From July 2011 to July 2013,92 children with chronic cough（ study group） and 104 children with acute upper respiratory infection（ control group） underwent thedetection for mycoplasma pneumoniae antibody（ MP-Ig M） by passive agglutination in our hospital. The incidence of mycoplasma pneumoniae infection was compared by chi-square between these two groups. And the clinical data of 38 cases of chronic cough due to mycoplasma pneumoniae infection were analyzed. Macrolide antibiotics sequential therapy was managed among the children to observe the curative effect.Results 38 caseswere with mycoplasma pneumoniae infection in the study group（41. 3%,38 /92）,13 cases in the control group（12. 5%,13 /104）,here was statistically significant between the two groups（ χ^2= 21. 04,P 0. 01）. The irritating cough was the common symptom of childrenwith chronic cough caused by mycoplasma pneumoniae infection,76. 3%（29 /38）of them were with WBCcounts of（4- 10） × 10^9/ L,71. 1%（27 /38） of them were with CRP less than 10 mg / L,63. 2%（24 /38） of them were with bilateral pulmonary changes in varying degrees. In the study group,macrolide antibiotics sequential therapy for the children with mycoplasma pneumoniae infection achieved a good clinical treatment effect with a rate of 92. 1%. Conclusion There is a closely relation between chronic cough inchildrenand Mycoplasma pneumoniae infection. Macrolide antibiotics could be a favorable choice for the treatment of chronic cough.
出处
《中华全科医学》
2015年第8期1296-1297,1327,共3页
Chinese Journal of General Practice
