摘要
目的探讨孕早期采用超声检测胎儿预部透明软组织（NT）厚度联合母亲血清妊娠相关血浆蛋白A（PAPPA）、游离口人绒毛膜促性腺激素（Fβ-hOG）水平检测在诊断胎儿唐氏综合征中的价值。方法对2823例孕周在10-14周的单胎孕妇，采用超声检测胎儿NT厚度，生化检测母亲血清PAPPA、Fβ-hCG水平；对胎儿NT厚度，母亲血清PAPPA、Fβ-hCG水平异常者进一步行产前染色体检查。将2823例孕妇按检测结果分为阴性组（胎儿唐氏综合征检测阴性）、阳性组（胎儿唐氏综合征检测阳性）与唐氏综合征组（染色体检查确诊胎儿患唐氏综合征），比较3组胎儿NT厚度，母亲血清PAPPA、Fβ-hCG水平的差异。结果2823例孕妇中，胎儿唐氏综合征阳性31例，阳性率为1．10％；31例阳性胎儿确诊唐氏综合征2例，检出率为0．71％。（2／2823）。与阴性组、阳性组比较，唐氏综合征组孕妇血清PAPPA水平显著降低（P〈O．05）、FBhCG水平显著升高（P〈O．05），胎儿NT厚度明显增厚（P〈O．05）。结论在孕早期对孕妇采用超声检测胎儿NT厚度联合母亲血清PPAPA、Fβ-hCG水平检测对诊断胎儿唐氏综合征有着积极的意义，可以减少因疾病给患者带来的身体和心理上的伤害。
ABSTRACT:Objective To investigate the value of combination of ultrasonic measurement of fe-tal nuchal translucency (NT)thickness and determination of maternal serum pregnancy-associat-ed plasma protein-A (PPAP-A)and free β human chorionic gonadotrophin (Fβ-hCG)levels in early pregnancy in the diagnosis of Down’s syndrome.Methods Fetal NT thickness was meas-ured by ultrasound and maternal serum PAPP-A and Fβ-hCG levels were determined at 10-14 weeks of gestation in 2 823 singleton pregnant women.Furthermore,prenatal chromosome exami-nation was performed in pregnant women with abnormalities in fetal NT thickness and maternal serum PAPP-A and Fβ-hCG levels.According to the results,these pregnant women were divided into negative group (negative for Down’s syndrome),positive group (positive for Down’s syn-drome)and Down’s syndrome group (confirmed by chromosome examination).Fetal NT thick-ness and maternal serum PAPP-A and Fβ-hCG levels were compared among the three groups.Re-sults Among the 2 823 pregnant women,Down’s syndrome screening results were positive in 31 (1.10%),and Down’s syndrome was confirmed in 2 (0.71‰).Compared with negative group and positive group,PAPP-A levels reduced,Fβ-hCG levels elevated and fetal NT thickness in-creased in Down’s syndrome group (P <0.05).Conclusion Screening for Down’s syndrome by ultrasonic measurement of fetal NT Thickness and determination of maternal serum PPAP-A and Fβ-hCG levels in early pregnancy can reduce the physical and psychological trauma caused by dis-eases.
出处
《实用临床医学（江西）》
CAS
2015年第5期73-76,共4页
Practical Clinical Medicine
