摘要
目的 观察地佐辛复合舒芬太尼用于乳腺癌改良根治手术后镇痛的效果.方法 将择期行乳腺癌改良根治术患者60例随机均分为A组和B组,手术结束前30 min静脉给予舒芬太尼0.1μg/kg,术后48 h行患者静脉自控镇痛（PCIA）,A组PCIA配方为地佐辛0.5 mg/kg＋舒芬太尼1μg/kg,B组PCIA配方为舒芬太尼2.0μg/kg,两组PCIA药物均用生理盐水稀释成100 ml,持续剂量2 ml/h,PCIA量每次0.5 ml.记录术后2 h（T1）、4 h（T2）、12 h（T3）、24 h（T4）、48 h（T5）疼痛视觉模拟评分（VAS）、Ramsay镇静评分及恶心、呕吐、皮肤瘙痒、呼吸抑制等不良反应.结果 两组配方均能为患者提供有效的术后镇痛,各时间点的VAS评分、Ramsay镇静评分组间比较均无统计学差异,A组不良反应较B组少,有统计学差异.结论 地佐辛复合舒芬太尼用于乳腺癌改良根治术后静脉镇痛效果好,可减少舒芬太尼的用量,不良反应少,可用于临床.
Objective To observe the effect of dezocine combined with sufentanil for patientcontrolled intravenous analgesia （PCIA） after breast cancer surgery.Methods 60 breast cancer patients undergoing modified radical mastectomy were selected and randomly divided into group A and group B,30 cases in each group.30 min before the end of the operation,0.1μg/kg sufentanil was injected by intravenous.PCIA was carried out 48 h after operation,0.5 mg/kg dezocine ＋ lμg/kg sufentanil in group A,and 2.0μg/kg sufentanil in group B.Drugs were diluted to 100 ml by adding normal saline,continuous dose with 2 ml/h,and PICA dose with 0.5 ml/time.Observed and recorded patients＇ visual analogue scale （VAS） and Ramsay sedation score 2,4,12,24,48 h after operation （T1-5） and adverse reactions such as nausea,vomiting,itching,respiratory depression.Results There were no statistically significant differences in VAS score and Ramsay sedation score at each time point between two groups （P〉0.05）.The rate of adverse reactions in group A was less than that in group B （P〈0.05）.Conclusion Dezocine combined with sufentanil for PCIA in modified radical mastectomy has good analgesia effect,with fewer adverse reactions,which can reduce the dosage of sufentanil,worthy of clinical application.
出处
《国际医药卫生导报》
2015年第14期1992-1994,共3页
International Medicine and Health Guidance News
关键词
地佐辛
舒芬太尼
术后镇痛
乳腺癌
Dezocine
Sufentanil
Postoperative analgesia
Breast cancer
