摘要
目的:观察结肠癌转移相关基因(MACC1)和肝细胞生长因子受体(C-met)蛋白在食管癌中的表达及意义。方法:采用免疫组织化学En Vinsion法检测88例食管癌组织中MACC1和C-met蛋白的表达情况,分析两者与食管癌病理分级、临床分期的关系及两者在食管癌组织中表达的相关性。结果:MACC1和Cmet在食管癌组织中的阳性率分别为88.64%和75.00%。在食管癌中MACC1和C-met蛋白高表达与临床分级、分期显著相关(P<0.001)。进一步分析显示食管癌组织中MACC1和C-met蛋白表达具有相关性。结论:食管癌组织中MACC1、C-met及其蛋白表达水平增高,C-met通路的激活和MACC1过表达可能与食管癌的发生、发展有关,MACC1和C-met具有作为食管癌分子标志物的潜在价值。
Objective：To investigate the exPressions and Prognostic significance of metastasis-associated in colon cancer 1（MACC1）and hePatocyte growth factor recePtor（C-met）in esoPhageal cancer. Methods：The exPression of MACC1 and C -met in 88 cases of Primary esoPhageal cancer were detected by immunohistochemical staining method. Results：The exPressions of MACC1 and C-met were significantly higher in esoPhageal cancer. The high ex-Pressions of MACC 1 and C -met were significantly related to differential Pathological stage and TNM stage（ P〈0. 001）,but not with gender,age. A Positive correlation was found between the high exPressions of MACC1 and C-met. Conclusion：The high exPressions of MACC1 and C-met may Play an imPortant role in the develoPment,Pro-gression and metastasis of esoPhageal cancer. The combined detection of MACC1 and C-met can be used to deter-mine the biological behavior and Prognosis of esoPhageal cancer.
出处
《现代肿瘤医学》
CAS
2015年第13期1843-1846,共4页
Journal of Modern Oncology
