摘要
脂联素是存在于白脂肪组织和棕脂肪组织中的激素,通过结合脂联素受体1,2及T-钙黏蛋白发挥作用。脂联素与肥胖、非酒精性脂肪肝(NAFLD)、糖尿病以及其他胰岛素抵抗状态呈负相关。脂联素缺乏除了会导致代谢紊乱外,还可引发冠状动脉硬化性心脏病、脂肪肝炎、胰岛素抵抗、NAFLD以及多种癌症。脂联素能调节多项细胞通路,如脂联素在肝脏及肌肉中具有增强腺苷酸活化蛋白激酶及过氧化物酶体增殖物激活受体α通路的作用。该文就脂联素与代谢性疾病的关系予以综述。
Adiponectin is a hormone existing in white and brown adipose tissues and acts through binding to its receptors adipoR1,AdipoR2,and T-cadheri. Adiponectin is negatively correlated with obesity,diabetes,nonalcoholic fatty liver disease（ NAFLD） and other insulin-resistant states. Apart from causing metabolic dysfunction,adiponectin deficiency may also contribute to coronary heart disease,steatohepatitis,insulin resistance,NAFLD,and a wide array of cancers. Adiponectin can mediate multiple molecular pathways,such as enhancing AMP-activated protein kinase and peroxisome proliferator activated receptor α pathway in the liver and skeletal muscle. Here is to make a review of the relationship between adiponectin and metabolic dysfunction.
出处
《医学综述》
2015年第12期2162-2164,共3页
Medical Recapitulate
关键词
非酒精性脂肪肝
脂联素
胰岛素
肥胖
Nonalcoholic fatty liver disease
Adiponectin
Insulin
Obesity
