摘要
1例73岁男性患者,确诊结肠中分化腺癌肝转移,无药物和食物过敏史。既往接受18个周期化疗,其中有9周期的奥沙利铂化疗史。后因病情进展更换化疗方案,再次使用奥沙利铂,静脉滴注奥沙利铂半小时左右,患者出现寒战、发热,体温最高达39℃,给予地塞米松磷酸钠注射液、盐酸苯海拉明注射液和吲哚美辛栓,寒战立刻缓解,2 h后体温恢复正常。之后两次继续输注奥沙利铂治疗均出现类似症状,对症处理后缓解,第3次出现症状后未再使用奥沙利铂。
One 73-year-old male patient was diagnosed with colon adenocarcinoma and liver metastasis, and had no allergic history of drug and food. The patient had received 18 cycles of chemotherapy before admission, including 9 cycles of oxaliplatin chemotherapy. We changed the chemotherapy regimen because of the progressive disease, and chose oxaliplatin again. Thirty minutes after the infusion of oxaliplatin, the patient developed chill and fever, and the body temperature reached to 39 ~C. The patient was treated with dexamethasone sodium phosphate, diphenhydramine hydrochloride, indometacin suppository. The chill relieved immediately, and the body temperature recovered 2 hours later. The same symptoms appeared in the next 2 times of infusions. The patient stopped using oxaliplatin after the third time of allergy.
出处
《中国药物应用与监测》
CAS
2015年第3期191-193,共3页
Chinese Journal of Drug Application and Monitoring
基金
吴阶平基金课题(320.6799.1110)
关键词
注射用奥沙利铂
发热
药品不良反应
Oxaliplatin for injection
Fever
Adverse drug reaction
