摘要
目的:观察尿毒清颗粒配合西医常规治疗对痛风性肾病肾功能的保护作用。方法:将99例患者随机按数字表法分为观察组49例和对照组50例。对照组在调整饮食习惯的基础上给予别嘌醇片,100 mg/次,2次/d,和碳酸氢钠片,1 g/次,3次/d。观察组在对照组治疗的基础上服用尿毒清颗粒,5 g/次,3次/d,温开水冲服。两组疗程均为12周。观察治疗前后24h尿蛋白定量(Upro),尿常规、肌酐(Cr),尿素氮(BUN),血尿酸(UA),胱抑素-C(Cys-C),β2-微球蛋白(β2-MG),尿N-乙酰-β-氨基葡萄糖苷酶(NAG)和黄嘌呤氧化酶(XOD)等指标变化情况,进行治疗前后脾肾亏虚,湿浊内阻证评分。结果:经Ridit分析,治疗后观察组疾病疗效和中医证候疗效均优于对照组(P<0.05);治疗后观察组Upro,Cr,BUN和UA水平均低于对照组(P<0.05,P<0.01);治疗后观察组XOD,Cys-C,β2-MG和NAG水平低于对照组(P<0.05,P<0.01)。结论:在生活方式干预及常规西医治疗的基础上,尿毒清颗粒能降低痛风性肾病患者Upro,Cr,BUN,UA水平,XOD,Cys-C,β2-MG和NAG水平,对肾功能具有一定的保护作用,其疾病疗效和中医证候疗效均优于单纯的西医治疗。
Objective： Discuss protection effect of Niaoduqing particles combined conventional western medicine therapy treat gouty nephropathy renal function. Method： Ninety-nine patients were randomly divided into control group （49 cases） and observation group （50 cases）. Patients in control group took allopurinol tablets on the basis of adjusting the diet habit, 100 mg/time, 2 does/day. Sodium bicarbonate tablets, 1 g/time, 3 does/ day. Based on the therapy in control group, patients in observation group added Niaoduqing particles, 5 g/time, 3 does/day, taken with boiled water. Treatment courses in two groups were both 12 weeks. Observe indicators changes as 24 h urine protein quantitative （Upro）, urine routine, creatinine （Cr）, blood urea nitrogen （BUN）, uric acid （UA）, urinary inhibition-C （Cys-C） , fl2-microglobulin （fl2-MG）, urinary n-acetyl-fl-amino glycosidase enzymes （NAG） and xanthine oxidase （XOD） before and after treatment. Score the lienal kidney deficient empty and wet muddy resistance card symptoms before and after therapy. Result： By Ridit analysis, the disease curative effect and traditional Chinese medicine syndrome curative effect in observation group were superior to those in control group （P 〈 0.05）. Levels of Upro, Cr, BUN and UA in observation group were inferior to the standards in control group （P 〈 0.05, P 〈 0.01 ）. XOD, Cys-C, fl2-MG and NAG in observation group were less than those in control group （P 〈 0.05, P 〈 0.01 ）. Conclusion： Based on lifestyle intervention and conventional western medicine treatment, Niaoduqing particles can reduce Upro, Cr, BUN, UA, XOD, Cys-C, flE-MG and NAG levels with gouty nephropathy disease. It has certain protective effect for renal function. Its disease curative effect and traditional Chinese medicine syndrome curative effect are superior to using western medicine therapy alone.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2015年第14期157-160,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
痛风性肾病
尿毒清颗粒
临床观察
Gouty nephropathy
Niaoduqing particles
clinical observation
