摘要
目的探究阿替普酶、尿激酶在急性肺栓塞溶栓治疗的临床疗效、不良反应,为急性肺栓塞临床选药提供参考。方法将80例急性肺栓塞纳入本次研究,随机分为研究组、对照组,分别采用阿替普酶、尿激酶治疗,同时采用2 h静脉溶栓治疗方案,在疗程结束后,对比两组患者临床疗效、不良反应发生率及死亡率等指标。结果溶栓24 h后,研究组总有效率97.5%,对照组总有效率75.00%,组间差异存在统计学意义(χ2=10.074,P=0.006<0.05);两组治疗前后组织型纤溶酶原激活物活性、心率降低,收缩压、舒张压、氧分压以及二氧化碳分压升高,差异有统计学意义(P<0.05),且两组治疗后组间数据差异有统计学意义(P<0.05);治疗后,研究组出现轻度出血病例1例,重度出血1例,对照组出现轻度出血病例6例,重度出血2例,组间数据比较无统计学差异(χ2=0.447,P=0.504>0.05);研究组死亡率为0.00%,对照组死亡率为2.5%,组间率差异无统计学意义(χ2=1.339,P=0.237>0.05)。结论阿替普酶、尿激酶两种药物对急性肺栓塞均有一定溶栓效果,采用阿替普酶药物治疗患者临床效果好,治疗有效率更高,对于急性肺栓塞患者溶栓治疗更有效。
Objective To compare the effectiveness and security of aheplase and urokinase in the treatment of acute pulmonary embolism thrombolysis, in order to provide reference for clinical medicine of acute pulmonary embolism. Methods 80 cases of acute pulmonary embolism were randomly divided into the research group and the control group, respectively given the treatment of alteplase and urokinase. All of them were given 2 hours＇ venous throm- bolysis. The clinical efficacy, the incidence of adverse reactions and mortality were compared. Results 24 hours after thrombolysis, the total effective rate was 97.5% in the research group and 75.00% in the control group （χ^2 = 10. 074, P = 0. 006 ）. In the two groups, the original tissue fibrinolytic enzyme activity activators, heart rate, systolic pressure, diastolic blood pressure, oxygen partial pressure and C02 partial pressure increased after the treatment （P 〈 0. 05 ） , and the improvement was more pronounced in the research group than in the control group （ P 〈 0. 05 ）. After the treatment, there were 1 case of mild bleeding, 1 case of severe bleeding in the research group, and 6 cases of mild bleeding, 2 cases of severe hemorrhage in the control group （ χ^2 = 0. 447, P = 0. 504 ）. The mortality was 0.0% in the research group and 2. 5 % in the control group （χ^2 = 1. 339, P = 0. 237 ）. Conclusion Alteplase has a better curative effect than urokinase in the treatment of acute pulmonary embolism thrombolysis.
出处
《临床肺科杂志》
2015年第8期1465-1468,共4页
Journal of Clinical Pulmonary Medicine
关键词
阿替普酶
尿激酶
急性肺栓塞
溶栓治疗
alteplase
urokinase
acute pulmonary embolism
fibrinolytic therapy
