摘要
目的探讨甲状腺髓样癌(MTC)的临床病理学特点。方法对8例甲状腺髓样癌患者的临床资料、免疫组化及病理组织学进行回顾性分析与研究。结果患者大多以体检发现颈部肿块就诊。肿瘤组织实体状,境界清楚,大部分无包膜,灰白至淡黄色;癌细胞呈巢状、岛状、滤泡状排列,细胞为胖梭形或多角形,核圆或卵圆形,核仁不清,胞质呈细颗粒状,嗜双染性,癌细胞巢周边有纤细的纤维血管间质、玻璃样变胶原组织及淀粉样物分隔。癌组织中降钙素(CT)、CEA、Cg A和Syn(+),而Tg、TPO、galectin-3和HBME-1(-)。结论 MTC具有多分化肿瘤的特点,可以表达多种神经内分泌标记物。对于有甲状腺结节的患者进行CT、CEA检测,并行甲状腺细针穿刺细胞学结合B超检查是MTC早期诊断、早期治疗、取得良好预后的最有效方法。
Objective To investigate the clinical and pathological characteristics of medullary thyroid carcinoma （MTC）.Methods The clinicopathologic data were collected in 8 cases of MTC confirmed by pathology.The tumors were retrospectively analyzed by light microscopy and immunohistochemistry.Results The majority of patients received medical treatment because of a neck mass.Tumor was well-demarcated but mostly non-enveloped,gray to yellowish on cut surface,and arranged in solid nests,island,or follicular pattern.Cancer cells were short spindle or polygonal,with round or oval nuclei,unconspicuous nucleolus,finely granular eosinophilic cytoplasm and metachromasia.Fibrovascular,hyalinized collagen or amyloid stroma separated the cancer nests.The tumor cells were positive for calcitonin （CT）,CEA,CgA,and Syn,but negative for thyroglobulin （Tg）,TPO,galectin-3 and HBME-1.Conclusions MTC has characteristics of the tumor with multiple differentiation,which can express a variety of neuroendocrine markers.For patients with thyroid nodules,detection of serum calcitonin and CEA,fine needle aspiration cytology combined with B ultrasound examination are of most effective to improve the early diagnosis,treatment and prognosis.
出处
《诊断病理学杂志》
CSCD
2015年第6期332-335,共4页
Chinese Journal of Diagnostic Pathology
关键词
甲状腺肿瘤
甲状腺髓样癌
临床病理特征
免疫组化
Thyroid neoplasms
Medullary thyroid carcinoma
Clinicopathological feature
Immunohistochemistry
