期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

软骨细胞周基质对软骨细胞作用的研究进展 被引量：5

Research on pericellular matrix properties for chondrcytes
在线阅读 下载PDF
导出
摘要 软骨细胞周基质(pericellular matrix,PCM)是软骨细胞周围的狭窄基质条带,与其包绕的软骨细胞共同组成软骨单位。大量研究表明PCM富含蛋白多糖、胶原蛋白和纤维蛋白,且在调节软骨细胞代谢微环境方面发挥着重要作用。用微管吮吸技术直接检测软骨单位发现,PCM与软骨细胞和软骨细胞外基质的力学特性明显不同。然而,关于PCM的功能还不是十分明确,仍需进一步研究。 Pericellular matrix（PCM） is a narrow tissue region surrounding chondrocytes,which ＂chondron＂ with its enclosed cells. A number of studies suggested that PCM is rich in proteoglycans,collagen and fibronectin,and plays an important role in regulating microenvironment of chondrocytes. Direct measures of PCM properties through micropipette aspiration technique showed that PCM was different from mechanical property of chondrocytes and nature extracellular matrix. However,the function of PCM is not clear,and need further study.
作者 韩俊亮 段王平 史光华 苑伟 卫小春
机构地区 山西医科大学第二医院骨科山西省骨与软组织损伤修复山西省重点实验室
出处 《中国骨伤》 CAS 2015年第6期576-579,共4页 China Journal of Orthopaedics and Traumatology
基金 国家自然基金(编号:31271033 31340010) 2013年山西省基础研究计划项目(编号:2013021036-3)~~
关键词 软骨细胞 细胞周基质 综述文献 Chondrocytes Pericellular matrix Revies literature
分类号 R285.5 [医药卫生—中药学]
  • 相关文献

参考文献33

  • 1段王平,孙振伟,卫小春.关节软骨中最基本的解剖功能结构:软骨单位(英文)[J].中国组织工程研究与临床康复,2010,14(24):4557-4560. 被引量：9
  • 2段王平,孙振伟,李琦,任立新,卫小春.兔膝关节软骨单位体外酶解法消化 分离的实验研究[J].中国药物与临床,2010,10(8):874-877. 被引量：8
  • 3Lee GM, Poole CA, Kelley SS, et al. Isolated chondrons:a viable alternative for studies of chondrocyte metabolism in virto[J]. Ostooarthritis Cartilage, 1997, 5(4):261-274.
  • 4Appelman TP, Mizrahi J, Seliktar D. A finite element model of cell-matrix interaction to study the differential effect of scaffold composition on chondrogenic response to the mechanical stimulation[J]. J Biomech Eng, 2011, 4:041010.
  • 5Vonk LA, Doulabi BZ, Huang CL, et al. Preservation of the chondrocyte\'s pericellular matrix improves cell-induced cartilage formation[J]. J Cellular Bioch, 2010, 110(1):260-271.
  • 6Poole CA, Ayad CA, Schofield JR. Chondrons from articular cartilage.(Ⅳ). Immunolocalization of proteoglycan epitopes in isolated canine tibial chondrons[J]. J Histochem Cytochem, 1991, 39(9):1175-1187.
  • 7Kvist AJ, Nystrom A, Hultenby K, et al. The major basement membrane components localize to the chondrocyte pericellular matrix-a cartilage basement membrane equivalent[J]. Matrix Biol, 2008, 27(1):22-33.
  • 8Poole CA. Articular cartilage chondrons:form, function and failure[J]. J Anat, 1997, 191(Pt1):1-13.
  • 9Zhang Z, Jin W, Beckett J, et al. A proteomic approach for identification and localization of the pericellular components of chondrocytes[J]. Histochem Cell Biol, 2011, 136(2):153-162.
  • 10Tillet E, Wiedemann H, Golbik R, et al. Recombinant expression and structural and binding properties of alpha1(Ⅵ) and alpha 2(Ⅵ) chains of human collagen type Ⅵ[J]. Eur J Biochem, 1994, 221(1):177-185.

二级参考文献36

  • 1王小虎,卫小春,陈维毅.软骨细胞力学特性的研究进展[J].中华医学杂志,2006,86(21):1502-1504. 被引量：11
  • 2王小虎,卫小春,张全有,陈维毅.正常软骨细胞力学特性的研究[J].中华医学杂志,2007,87(13):916-920. 被引量：5
  • 3李春江,卫小春.软骨细胞骨架研究进展[J].生物骨科材料与临床研究,2007,4(2):24-26. 被引量：7
  • 4Poole CA.Articular cartilage chondrons:form,function and failme.J Anat,1997,191(1):1-13.
  • 5Kvist A,Nystrom A,Hultenby K,et al.The major basement membrane components localize to the chondrocyt pericellular matrix:a cartilage basement membrane equivalent.Matrix Biology,2008,27:22-33.
  • 6Guilak F,Alexopoules LG,Haider MA,et al.Zonal uniformity in mechanical properties of the chondrocyte ericellular matrix:micropipette aspiration of canine chondrons isolated by cartilage homogenization.Ann Biomed Eng,2005,10:1312-1318.
  • 7Poole CA,Glant TT,Schofield JR.Chondrons from articular cartilage (Ⅳ):Immunolocalization of proteoglycan epitopes in isolated tibiai chondrons.J Histochem Cytochem,1991,39:1175-1187.
  • 8Lee GM,Poole CA,Kelley SS,et al.Isolated chondrons:a viable alternative for studies of chondrocyte metabolism in virto.Ostooarthritis Cartilage,1997,5:261-274.
  • 9Salmivirta K,Talts JF,Olsson M,et al.Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogens.Exp Cell Res,2002,279:188-201.
  • 10Guilak F,Jones WR,Ting-Beall HP,et al.The deformation behavior and mechanical properties of chondrocytes in articular cartilage.Osteoarthritis Cartilage,1999,7:59-70.

共引文献13

同被引文献106

  • 1彭磊,胡蕴玉,徐华梓,王臻,许松峰,孙峥,王胜.间歇性压力培养环境对兔骨髓基质干细胞增殖的影响[J].中国骨伤,2007,20(2):92-93. 被引量：6
  • 2宋关斌,汪露,申晓东,秦建,石轶松,罗庆,杨力.机械拉伸刺激对大鼠骨髓间充质干细胞增殖的调节[J].医用生物力学,2007,22(1):15-20. 被引量：9
  • 3刘天一,周广东,魏娴,武晓莉,陈付国,崔磊,刘伟,曹谊林.转化生长因子β_1诱导时间对骨髓基质细胞体外成软骨分化的影响[J].中华医学杂志,2007,87(31):2218-2222. 被引量：7
  • 4Taddei R,Queiroz-Junior CM,Moura AP,et al. The effect of CCL3 and CCR1 in bone remodeling induced by mechanical loading during orthodontic tooth movement in mice[J]. Bone,2013,52(1 ):259- 267.
  • 5Takano-Yamamoto T. Osteocyte function under compressive me- chanical force[J]. Jap Dental Sei Rev, 2014,50 ( 2 ) : 29-39.
  • 6Thompson WR, Rubin CT, Rubin J. Mechanical regulation of sig- naling pathways in bone [J]. Gene ,2012,503 (2) : 179-193.
  • 7Brohawn SG,Su Z, MacKinnon R. Mechanosensitivity is mediateddirectly by the lipid membrane in TRAAK and TREK1 K+ channels [J ]. Proc Nat Acad Sci USA, 2014,111 (9) : 3614-3619.
  • 8Humphrey JD ,Dufresne ER,Schwartz MA. Mechanotransduction and extracellular matrix homeostasis[J]. Nat Rev Mol Cell Bi- o1,201d, 15(12) :802-812.
  • 9Formigli L, Meacci E, Sassoli C, et al. Cytoskeleton/stretch - acti- vated ion channel interaction regulates myogenic differentiation of skeletal myoblasts [ J ]. J Cellu Physiol, 2007,211 (2) : 296-306.
  • 10Zhong Z ,Zeng XL,Ni JH,et al. Comparison of the biological re- sponse of osteoblasts after tension and compression [J ]. Eur J Or- thod,2013,35 (1) :59-65.

引证文献5

二级引证文献17

中国骨伤
2015年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部