摘要
目的探讨高频振荡机械通气(high frequency oscillatory ventilation,HFOV)治疗新生儿气胸的效果及安全性。方法 36例需行机械通气治疗的气胸患儿,依据治疗方法分为2组,行HFOV治疗者19例为HFOV组,常频机械通气(conventional mechanical ventilation,CMV)治疗者17例为CMV组,记录2组呼吸机治疗前及治疗12、24h时pa(O2)、pa(CO2)、氧合指数(oxygenation index,OI)水平变化,比较2组呼吸机使用时间、X线胸片恢复正常时间。结果 2组治疗前pa(CO2)、pa(O2)及OI比较差异均无统计学意义(P>0.05);HFOV组治疗12、24h时pa(CO2)[(5.19±0.79)、(4.71±0.42)kPa]、OI(17.85±5.31、15.20±3.43)较治疗前[(7.41±0.07)kPa、(30.64±7.84)]下降(P<0.05),pa(O2)[(7.10±0.81)、(8.76±1.35)kPa]较治疗前[(5.53±0.66)kPa]增高(P<0.05);CMV组治疗12、24h时pa(CO2)[(6.63±0.84)、(6.05±0.99)kPa]、OI(24.44±5.07、20.19±3.73)较治疗前[(7.51±0.95)kPa、(34.28±6.95)]下降(P<0.05),pa(O2)[(6.39±0.65)、(7.51±1.21)kPa]较治疗前[(5.46±0.70)kPa]增高(P<0.05);HFOV组治疗12、24h时pa(CO2)、pa(O2)、OI较CMV组改善明显(P<0.05);HFOV组呼吸机使用时间[(3.53±1.09)d]较CMV组[(6.63±0.84)d]短(P<0.05),X线胸片恢复正常时间[(3.45±1.08)d]较CMV组[(4.59±1.50)d]短(P<0.05)。结论与CMV相比,HFOV可较好改善气胸患儿的氧合功能,缩短呼吸机使用时间和气胸吸收时间。
Objective To evaluate the effect and safety of high frequency oscillatory ventilation (HFOV) in the treatment of neonatal pneumothorax. Methods A total of 36 patients with neonatal pneumothorax needing mechanical ventilation were divided into HFOV group (n= 19) and conventional mechanical ventilation (CMV) group (n= 17). The changes of pa (O2), pa (CO2) and oxygenation index (OI) were recorded, and the mechanical ventilation time and the time of chest X-ray returning to normal were monitored in 0, 12 and 24 hours. The outcomes were compared between two groups. Results There were no significant differences in pa(O2 ), pa(COz ) and OI before treatment between two groups (P〈 0.05). In HFOVgroup, the pa(CO2) values ((5.19±0.79), (4.71±0.42) kPa) and the OI values (17.85±5.31, 15.20± 3.43) after 12- and 24-hour treatment were significantly lower than those before treatment (pa(CO2) : (7.41 ± 0.07) kPa, OI: 30.64±7.84), and the pa(O2) values ((7. 10±0.81), (8.76±1.35) kPa) were significantly higher than that before treatment ((5.53±0. 66) kPa) (P〈0.05). In CMV group, the pa(CO2) values ((6. 63±0. 84), (6. 05±0.99) kPa) and the OI values (24.44±5.07, 20.19±3.73) after 12- and 24-hour treatment were significantly lower than those before treatment (pa(CO2): (7.51±0.95) kPa, OI: 34. 28±6.95), and the pa(O2)values ((6.39±0.65), (7.51±1.21) kPa) were significantly higher than that before treatment ((5.46±0.70) kPa) (P〈0. 05). The pa(O2), pa(CO2) and OI values after 12- and 24-hour treatment were improved more greatly in HFOV group than in CMV group (P〈0. 05). The ventilation time ((3. 53 ± 1. 09) d) and the time of chest X-ray returning to normal ((3.45±1.08) d) were shorter in HFOV group than those in CMV group ((6. 63±0. 84), (4. 59±1. 50) d) (P〈 0.05). Conclusion HFOV is superior to CMV in improving the pulmonary function of newborns with pneumothorax and shortening both mechanical ventilation time and the time of chest X-ray returning to normal.
出处
《中华实用诊断与治疗杂志》
2015年第7期687-688,691,共3页
Journal of Chinese Practical Diagnosis and Therapy
关键词
气胸
新生儿
高频振荡通气
常频机械通气
Pneumothorax
newborns
high frequency oscillatory ventilation
conventional mechanical ventilation