摘要
目的考察内镜下粘膜切除术（EMR）和粘膜剥离术（ESD）治疗消化道早癌的短期疗效。方法选取消化道早癌患者80例，分别采取ESD（40例）和EMR（40例）治疗。比较两组患者完全切除率、整块切除率、术中出血率、术中穿孔率、术后并发症发生率和1年内复发率。结果ESD组整块切除率和完全切除率分别为97．5％和92．5％，显著高于EMR组的77．5％和70．0％（P〈0．01）。EMR组术中出血率为2．5％，显著低于ESD组的7．5％（P〈0．05）。ESD组穿孔率为0，与EMR组（2．5％）比无统计学差异（P〉0．05）。两组间术后恢复情况无统计学差异（P〉0．05）。ESD组患者出现1例切口感染，EMR组无明显术后不良反应，两组间无统计学差异（P〉0．05）。ESD组1年内复发率为2．5％，显著低于EMR组的7．5％（P〈0．05）。结论内镜下粘膜剥离术治疗消化道早癌临床疗效更优。
Objective To investigate short - term efficacy of endoscopic mucosal resection （EMR） and endoscopic submucosal dissection（ ESD） in the treatment of gastrointestinal tumors. Methods 80 patients with gastrointestinal tumor were randomly divided into ESD group and EMR group with 40 cases in each group. The complete resection rate, whole block resection rate, intraoperative bleeding rate, intraoperative perforation rate, postoperative morbidity rate and 1 year survival rate were compared between the two groups. Results The whole block resection rate （97.5%） and complete resection rate（92.5% ）in ESD group were significantly higher than those in EMR group（77.5% and 70.0% ）（ P 〈 0.01 ）. The intraoperative bleeding rate in control group was 2.5% , which was significantly lower than that in ESD group （7.5 % ） （ P 〈 0.05 ）. The rate of perforation was 2.5 % in EMR group versus 0 in ESD group. There was no significant difference between the two groups（P 〉 0.05 ）. There was no significant difference in postoperative recovery between the two groups （ P 〉 0.05 ）. There were 1 case of wound infection in ESD group, while no obvious ad- verse reaction occurred in EMR group. There was no significant difference between the two groups （ P 〉 0.05 ）. 1 year recurrence rate in ESD group was 2.5% versus 7.5% in control group. There was significant difference between the two groups （ P 〈 0.05 ）. Conclusion Endoscopic submucosal dissection is more effective in the treatment of gastrointestinal tumor.
出处
《医学新知》
CAS
2015年第3期190-192,共3页
New Medicine
关键词
食管癌
胃癌
大肠癌
粘膜切除术
粘膜剥离术
Esophageal cancer
Gastric cancer
Colorectal cancer
Endoscopic mucosal resection
Endoscopic submueosal dissection
