摘要
目的分析系统性红斑狼疮(systemic lupus erythematosus,SLE)患者血液系统损害的特点,并探讨其临床意义。方法回顾性分析2011年1月至2014年6月本院确诊的150例SLE患者的临床资料,总结其血液系统损害特点。将患者分为对照组(无血液系统损害)和观察组(血液系统损害),比较两组患者疾病活动情况、可提取性核抗原(ENA)抗体阳性率及免疫细胞因子水平。结果 150例SLE患者中,116例(77.3%)出现血液系统损害,其中贫血91例(60.7%),白细胞减少49例(32.7%),血小板减少58例(38.7%)。与对照组相比,观察组患者疾病无活动例数明显减少,疾病轻、中和重度例数明显增多,观察组患者抗小核糖体核蛋白抗体(Anti-Sm)和抗核糖蛋白抗体(Anti-RNP)阳性率明显高于对照组(P<0.05),而抗双链DNA抗体(Anti-ds DNA)、抗Ro抗体(Anti-SSA)和抗La抗体(Anti-SSB)阳性率组间比较差异无显著性(P>0.05)。观察组患者白细胞介素(IL)-2、IL-6和肿瘤坏死因子-α(TNF-α)水平显著高于对照组(P<0.05)。结论 SLE患者并发血液系统损害常见,以贫血最常见。同时,存在血液系统损害的SLE患者疾病活动程度更严重,相关抗体阳性率和免疫细胞因子水平更高,给患者健康及生命造成更大威胁。
Objective To analyze the characteristics of hematological disorders in patients with systemic lupus erythematosus（SLE） and its clinical significance. Method 150 cases of diagnosed SLE patients in our hospital from January 2011 to June 2014 were enrolled into the study to investigate their characteristics of hematological disorders. All patients were divided into control group（without hematological disorders） and observation group（hematological disorders）. The activity of the disease, the positive rate of anti-extractable unclear antigen（ENA） antibodies and concentrations of immunological factors were detected and compared. Result Among the 150 SLE patients, 116 cases（77.3%） had hematological disorders. And anemia in 91 cases（60.7%）, leukopenia 49 cases（32.7%）, thrombocytopenia 58 cases（38.7%）. Compared with control group, cases with no activity were statistically less and cases with mild activity, moderate activity, severe activity were statistically more in observation group（P〈0.05）. After comparison, the positive rate of Anti-Sm and Anti-RNP in observation group was statistically higher than that in control group respectively（P〈0.05）, while the positive rates of Anti-ds DNA, Anti-SSA and Anti-SSB were statistically same in the two groups（P〉0.05）. As to immunological factors, concentration of IL-2, IL-6 and TNF-α in observation group were statistically higher than that in control group respectively（P〈0.05）. Conclusion Hematological disorders are common in SLE patients, of which anemia is the most common finding. At the same time, SLE patients with hematological disorders show a higher degree of severity of the activity, higher positive rates of associated antibodies and higher concentrations of immunological factors, which threatens patients＇ health and life more.
出处
《中国医学前沿杂志（电子版）》
2015年第5期100-102,共3页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
系统性红斑狼疮
血液系统损害
贫血
白细胞减少
血小板减少
Systemic lupus erythematosus
Hematological disorders
Anemia
Leukocytopenia
Thrombo-cytopenia
