摘要
目的 :探讨铝对家兔血清及脑组织中铜、锌、锰含量及SOD、GSH Px活力的影响和对神经细胞的毒性。方法 :在比利时纯种兔饲料中加入不同剂量的铝盐 ,测定兔血清及脑组织中的铝、铜、锌、锰含量及SOD、GSH Px活力 ,并进行细胞形态学观察。结果 :随着铝摄入量的增加 ,血清及脑铝含量增加 ,而铜、锌、锰含量则降低 ,血清中SOD、GSH Px活力与铝摄入水平呈负相关 ,脑组织中SOD活力低、高剂量组均高于对照组 ,GSH Px活力低剂量组与对照组无统计学差异 ,高剂量组则高于对照组。形态学观察发现 ,随着铝摄入量的增加 ,神经细胞出现变性、轴突消失等中毒症状。结论 :铝通过干扰体内铜、锌、锰等微量元素的代谢而影响机体的抗氧化能力 ,这可能是铝发挥神经毒作用的重要途径之一。
Objective: To inquire into the effects of different aluminum (Al) levels on trace elements Copper (Cu), Zinc (Zn) and Manganese (Mn), and on the anti oxidation enzyme system in the serum and brain of rabbits and the toxicity to neurons. Methods : Different doses of alum were added to the feed of twenty Belgium rabbits. The concentrations of Al,Cu,Zn,Mn in the serum and brain tissue were measured, the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH Px) were detected, and the morphology of brain cells observed. Results: The Al levels in the serum and brain remarkably rose with the increase of Al intake and the Cu,Zn and Mn levels significantly dropped. The activity of serum SOD and GSH Px correlated negatively with Al levels. SOD activity of brain in Al loaded groups was higher than in the control group. GSH Px activity of brain in high Al dose group was higher than in the control group,whereas no significant difference was observed between the low Al dose group and control group. Cytomorphological study showed that the neurons degenerated with the increase of Al intake. Conclusion: Aluminum influences the body's capacity of anti oxidation by interfering with body's level of trace elements Cu,Zn and Mn.This may be one of the important ways in which aluminum develops toxicity to the neurons.
出处
《山东大学学报（医学版）》
CAS
2002年第4期324-325,328,共3页
Journal of Shandong University:Health Sciences
基金
山东省卫生厅资助课题
