摘要
目的探讨托烷司琼联合地塞米松预防高危人群术后恶心呕吐发生的有效性。方法择期手术患者186例,根据麻醉方法的不同将患者分为地塞米松组、托烷司琼组和地塞米松联合托烷司琼组,每组62例。地塞米松组患者均在全身麻醉诱导后静脉注射地塞米松5 mg;托烷司琼组患者均在手术结束前静脉注射托烷司琼2 mg;地塞米松联合托烷司琼组患者均在全身麻醉诱导后静脉注射地塞米松5 mg,手术结束前静脉注射托烷司琼2 mg。记录患者拔管后0~2、2~6、6~24 h恶心、呕吐/干呕发生的例数,并记录需补救治疗的患者例数。结果患者拔管后0~2 h恶心、呕吐、需补救治疗患者地塞米松组显著多于托烷司琼组和地塞米松联合托烷司琼组（P〈0.05）,托烷司琼组显著多于地塞米松联合托烷司琼组（P〈0.05）;2~6 h地塞米松组和托烷司琼组患者恶心、呕吐、需补救治疗患者显著多于地塞米松联合托烷司琼组（P〈0.05）,托烷司琼组和地塞米松组间比较差异无统计学意义（P〉0.05）;6~24 h托烷司琼组患者恶心、呕吐、需补救治疗患者显著多于地塞米松组和地塞米松联合托烷司琼组（P〈0.05）,地塞米松组显著多于地塞米松联合托烷司琼组（P〈0.05）。结论托烷司琼复合地塞米松可有效降低高危患者术后恶心呕吐发生率。
Objective To investigate the effect of tropisetron combined with dexamethasone to prevent postoperative nausea and vomiting for high risk patients. Methods One hundred and eighty-six patients who received selective operation were randomly divided into three groups including dexamethasone group,tropisetron group,dexamethasone combined with tropisetron group,62 patients in each group. The patients in dexamethasone group were given dexamethasone 5 mg intravenously after anesthesia induction. The patients in tropisetron group were given tropisetron 2 mg intravenously at the end of surgery. The patients in dexamethasone combined with tropisetron group were given dexamethasone 5 mg intravenously after anesthesia induction and tropisetron 2 mg intravenously at the end of surgery. The case number of nausea episode and vomiting episode was recorded at the time of 0- 2,2- 6,6- 24 h after tracheal extubation. If rescue medication was used,the case number was also recorded. Results The case number of nausea,vomiting and using rescue medication of dexamethasone group was higher than that of tropisetron group and dexamethasone combined with tropisetron group at the time of 0- 2 h（ P〈0. 05）,while it was higher in tropisetron group than that in dexamethasone combined with tropisetron group at the time of 0- 2 h（ P〈0. 05）. The case number of nausea,vomiting and using rescue medication of dexamethasone group and tropisetron group was higher than that of dexamethasone combined with tropisetron group at the time of 2- 6 h（ P〈0. 05）,but there was no statistical significance between dexamethasone group and tropisetron group（ P〈0. 05）. The case number of nausea,vomiting and using rescue medication of tropisetron group was higher than that of dexamethasone group and dexamethasone combined with tropisetron group,while it was higher in dexamethasone group than that in dexamethasone combined with tropisetron group at the time of6- 24 h（ P〈0. 05）. Conclusion Tropisetron combined with dexamethasone can effectively prevent postoperative nausea and vomiting for high risk patients.
出处
《新乡医学院学报》
CAS
2015年第7期666-668,共3页
Journal of Xinxiang Medical University
关键词
托烷司琼
地塞米松
恶心呕吐
高危患者
tropisetron
dexamethasone
nausea and vomiting
high risk patients
