摘要
华法林是临床广泛应用的口服抗凝药,用于预防和治疗深静脉血栓、肺栓塞、慢性心房颤动、缺血性脑卒中及心脏瓣膜置换术后。华法林治疗指数小、个体剂量差异大,在诱导阶段如果过分抗凝有出血危险,而抗凝不足则可能血栓形成。遗传因素是造成华法林个体剂量差异的主要因素,其他因素如身高、体质量、合并用药等也可影响华法林的剂量。本文对近年来国内外基于遗传及临床因素建立的华法林剂量预测模型,以及模型在临床实际应用的进展作一综述。
Warfarin is a popular prescribed oral anti-coagulation, which is used to prevent and treat deep venous thrombosis, pulmonary thrombosis, chronic atrial fibrillation, cerebral arterial thrombosis and after cardiac valve replacement. Since the therapeutic index is small and the individual difference is great, bleeding would happen if over- coagulation, and thrombosis would happen if under coagulation. Researches show that genetic factors play an important role in the individual difference of warfarin, and other factors such as the height, body mass and combination of drug could also affect warfarin doses. This paper summarizes warfarin dose algorithms based on genetic and non-genetic factors home and abroad, and the latest development of its clinical application.
出处
《中华实用诊断与治疗杂志》
2015年第8期729-730,共2页
Journal of Chinese Practical Diagnosis and Therapy
基金
国家自然科学基金(81270300)
