摘要
儿童恶性肿瘤是指一大类儿童时期的恶性疾病，包括2大部分：血液淋巴系统疾病和实体肿瘤，多见于15岁以下的儿童。实体肿瘤是儿童恶性肿瘤的主要组成部分，与成人实体瘤有很大差别，以母细胞源性的肿瘤为主。其发病机制除与遗传、环境2大因素有关外，可能与母亲在怀孕期甚至怀孕前期对各种政癌性环境因素暴露有密切的因果联系。胎盘是母胎进行物质交换的器官，是胚胎与母体组织的结合体，部分与胎儿在生物学和基因学上同源，同时为胎儿在宫内正常发育提供全方位保障。现对儿童恶性肿瘤病因学及其与胎盘病变的关系进行综述，以期对儿童肿瘤的病因学研究和早期诊断有所帮助。
Childhood cancers are malignancies occured during childhood, which consist of blood - lymphatic system disorders and solid tumor,usually under the age of 15 years old. Among cancers of childhood, solid tumors ac- count for the mainly proportion and most neoplasms are embryonic origin, which are distinctly different from the adult solid tumors. The pathogenesis of children with an oncologic disease, except from the 2 major elements heredity and en- vironment, some experts consider that there are intense correlations between various carcinogenic environment exposure during pregnancy even progestation and childhood cancers. The placenta is a combination of embryo and the maternal tissues, while is a material exchanged organ between 2 parts. One part has a same origin with fetus biological and gene- tics, and the other provides comprehensive guarantee for fetus normal development in utero. The research of the placen- tal disease of childhood cancers may have a breakthrough in the study of the etiology of pediatric oncology.
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2015年第15期1193-1195,共3页
Chinese Journal of Applied Clinical Pediatrics
