摘要
目的分析噻托溴铵联合无创正压通气治疗慢性阻塞性肺疾病急性加重合并Ⅱ型呼吸衰竭的临床效果。方法收集2010年2月~2014年2月在本院诊治的92例慢性阻塞性肺疾病急性加重合并Ⅱ型呼吸衰竭患者作为研究对象,将其随机分为观察组（46例）与对照组（46例）。所有患者均实施呼吸内科常规治疗,在此基础上,对照组给予患者无创正压通气治疗,观察组应用噻托溴铵与无创正压通气联合治疗。观察两组的治疗效果、住院时间、再次入院率和累计死亡率。结果观察组患者的治疗总有效率为95.65%,显著高于对照组的80.43%,差异有统计学意义（P〈0.05）。观察组患者的住院时间为（11.24±3.41）d,显著短于对照组的（16.44±4.12）d（P〈0.05）。观察组患者的再次入院率、累计死亡率分别为21.74%、0%,均显著低于对照组（P〈0.05）。结论慢性阻塞性肺疾病急性加重合并Ⅱ型呼吸衰竭治疗中应用噻托溴铵与无创正压通气联合治疗具有良好的临床效果,患者预后良好。
Objective To analyze the clinical effect of of tiotropium bromide combined with non-invasive positive pres-sure ventilation in the treatment of acute exacerbation of chronic obstructive pulmonary disease with type II respiratory failure. Methods 92 patients with acute exacerbation of chronic obstructive pulmonary disease with type II respiratory failure admitted into our hospital from February 2010 to 2014 February were collecteg as research object.They were randomly divided into Observation group （46 cases） and control group （46 cases）.All patients were received the conven-tional treatment of respiratory department of internal medicine,on this base the control group was received noninvasive positive pressure ventilation.In the observation group was received tiotropium bromide with noninvasive positive pres-sure ventilation combined treatment.The overall treatment effect,hospital stay,readmission rate and cumulative mortality in two groups was observed. Results The total effective rate of observation group was 95.65%,significantly higher than 80.43% of control group,there was statistical significance （P〈0.05）.The average length of stay in observation group was （11.24±3.41） d,significantly shorter than that of control group[（16.44±4.12）] d（P〈0.05）.The readmission rate and cumu-lative mortality rate in observation group respectively was 21.74%、0%,significantly lower than that of control group（P〈0.05）. Conclusion The combined treatment of tiotropium bromide and non-invasive positive pressure ventilation has good clinical efficacy in the treatment of acute exacerbation of chronic obstructive pulmonary disease with type II res-piratory failure,patients with good prognosis.
出处
《中国当代医药》
2015年第22期118-120,共3页
China Modern Medicine
关键词
慢性阻塞性肺疾病
Ⅱ型呼吸衰竭
噻托溴铵
无创正压通气
临床疗效
Chronic obstructive pulmonary disease
Type II respiratory failure
Tiotropium bromide
Non-invasive posi-tive pressure ventilation
