摘要
目的探讨精神分裂症患者临床特征的性别差异。方法连续入组住院治疗的符合《国际疾病分类(第10版)》(ICD-10)精神分裂症诊断标准的患者334例,采用阳性和阴性症状量表(PANSS)、自知力与治疗态度问卷(ITAQ)、药物态度清单(DAI)、副反应量表(TESS)及健康状况问卷(SF-36)测评患者治疗前后的临床特征。采用χ2检验、t检验及协方差分析对临床特征进行性别差异比较。结果男性患者发病年龄小于女性(P<0.05),女性患者已婚比例高(P<0.05),治疗后女性患者ITAQ评分、DAI评分、SF-36评分低于男性(P均<0.05),TESS评分、PANSS阳性症状评分及抑郁症状评分高于男性(P均<0.05)。结论女性精神分裂症患者与男性相比,发病年龄晚,已婚比例高,抑郁症状重,对药物的副反应敏感。
Objective To explore the gender differences in clinical features of patients with schizophrenia. Methods A convenience sample consisted of 334 in- patients with schizophrenia. Clinical features were assessed before and after treatment by the Positive and Negative Syndrome Scale( PANSS),the Insight and Treatment Attitudes Questionnaire( ITAQ),the Drug Attitude Inventory( DAI),the Treatment Emergent Symptoms Scale( TESS),and the Short Form 36 Health Survey Questionnaire( SF- 36). Apply Chi- square test,t- test and covariance analysis to compare the gender differences of clinical features. Results Age of onset was younger in male patients( P < 0. 05),and most female patients were married( P < 0. 05). After treatment,scores of ITAQ,DAI,and health status in female patients were lower than male( P < 0. 05),while scores of TESS,positive symptoms and depressive symptoms of PANSS were higher than male( P < 0. 05). Conclusion The following factors were significantly associated with the female schizophrenia patients: later age of onset,married,more severe depressive symptoms and more medication side- effects.
出处
《四川精神卫生》
2015年第4期299-302,共4页
Sichuan Mental Health
基金
国家精神科临床重点专科建设项目子项目基金(201201-001)
广州市医药卫生科技基金(20131A011083)
关键词
精神分裂症
临床特征
性别差异
Schizophrenia
Clinical features
Gender difference
