摘要
目的探讨糖尿病心肌病患者AT1-AAs与VEGF的相关性。方法选择糖尿病心肌病患者33例,2型糖尿病患者35例以及健康体检者30例为研究对象,检测三组患者血清血管内皮生长因子水平、血管紧张素Ⅱ1型受体自身抗体水平,分析两者的相关性。结果糖尿病心肌病组患者的血清VEGF水平显著高于糖尿病组和对照组,差异有统计学意义(P<0.01);糖尿病组显著高于对照组,差异有统计学意义(P<0.01)。糖尿病心肌病组的血管紧张素Ⅱ1型受体抗体阳性率显著高于糖尿病组和对照组(P<0.01)。糖尿病心肌病组患者心脏重度扩大患者血清VEGF水平最高,其次为中度扩大患者,轻度扩大患者最低,差异有高度统计学意义(P<0.01)。血管紧张素Ⅱ1型受体自身抗体阳性患者血清VEGF水平显著高于阴性患者,差异有高度统计学意义(P<0.01)。相关性分析结果显示两者有显著相关性(r=0.271,P<0.01)。结论血清VEGF水平以及AT1-AAs与糖尿病心肌病的发生以及发展均具有相关性,并且AT1-AAs和VEGF水平也具有相关性。
Objective To discuss correlation of diabetic cardiomyopathy AT1-AAs and VEGF. Methods Thirty-three patients with diabetic cardiomyopathy, 35 patients with type 2 diabetes and 30 cases healthy people were selected for the study. AT1-AAs and VEGF were detected, and the correlation was analyzed. Results Serum VEGF levels in dia- betic cardiomyopathy patients was significantly higher than the diabetic group and the control group, and the difference was statistically significant （P〈0.01）; VEGF levels in diabetic group was significantly higher than control group, and the difference was statistically significant （P〈0.01）. Serum VEGF levels in diabetic cardiomyopathy patients with severe car- diomyopathy expand was the highest, followed by patients with moderate to expand, the lowest in patients with mild to expand, and the difference was statistically significant （P〈0.01）. Serum VEGF levels in patients with positive AT1-AAs were significantly higher in patients with negative AT1-AAs, and the difference was statistically significant （P〈0.01）. Correlation analysis showed significant correlation between AT1-AAs and VEGF（r=0.271, P〈0.01）. Conclusion Serum VEGF level and AT1-AAs are relevant with the incidence and development of diabetic cardiomyopathy, and AT1-AAs and VEGF levels are correlated.
出处
《中国现代医生》
2015年第22期34-36,共3页
China Modern Doctor
