摘要
目的观察枳术党参颗粒的肠推进和镇吐作用。方法采用阿托品、多巴胺以及肾上腺素诱导肠功能低下小鼠模型,研究枳术党参颗粒的肠推进作用;通过硫酸铜和顺铂诱导的家鸽呕吐模型,观察枳术党参颗粒的镇吐作用。结果枳术党参颗粒20 g/kg 1次给药能提高由阿托品抑制的小鼠肠推进活动,枳术党参颗粒10、20 g/kg 3次预防给药能提高多巴胺和肾上腺素抑制的小鼠肠推进活动;枳术党参颗粒16 g/kg 1次给药能减少硫酸铜所致家鸽的呕吐次数,枳术党参颗粒(4、8、16 g/kg)3次给药对顺铂所致家鸽的呕吐无明显作用。结论枳术党参颗粒有明显的促进小鼠肠排空作用,对外周呕吐有一定的镇吐作用。
Objective To study the temtic effect in animals. Methods effects of zhizhu dangshen granules The models of intestinal dysfunction on intestinal propulsive function and an- induced by atropine, dopamine and epi- nephrine in mice were used to study gastrointestinal propulsive function. The models of vomit induced by copper sulfate and cisplatin in pigeon were used to study antemtic effect. Results A single administration of Zhizhu dang- shen granules （20 g/kg） could alleviate inhibition of intestinal propulsive function induced by atropine in mice. Three preventive administration of Zhizhu dangshen granules （10 g/kg and 20 g/kg） could improve the inhibition of intestinal propulsive function induced by dopamine and epinephrine in mice. A single administration of Zhizhu dangshen granules （16 g/kg） could reduce the vomitive times induced by copper sulfate in pigeon. Three preven- tive administration of Zhizhu dangshen granules （4 g/kg, 8 cisplatin in pigeon. Conclusion Zhizhu dangshen granules also has certain antiemetic effect on peripheral vomit. g/kg and 16 g/kg） had no effect on vomit induced by significantly increases intestinal propulsive function. It
出处
《安徽医科大学学报》
CAS
北大核心
2015年第9期1286-1289,共4页
Acta Universitatis Medicinalis Anhui
基金
安徽高校省级自然科学研究项目(编号:KJ2012A176)
关键词
枳术党参颗粒
肠推进作用
镇吐作用
Zhizhu dangshen granules
intestinal propulsive effect
analgesic effect
