摘要
以中药为主的天然产物有效部位或成分通过降低黄嘌呤氧化酶或/和腺苷脱氨酶活性而减少尿酸生成,或者调控表达异常的尿酸盐转运体而促进尿酸的排泄,从而发挥抗高尿酸血症的药理作用。本文综述了抗高尿酸血症的天然产物相关实验研究,阐述了以中药为主的天然产物有效部位或成分治疗高尿酸血症的药理机制,以期为抗高尿酸血症的新药研究和痛风的中医药治疗提供参考。
Many natural products,mainly from Chinese herbs,showed significant anti-hyperuricemia activity through decreasing the generation of uric acid by reducing the activity of xanthine oxidase or/and adenosine deaminase,and promoting the excretion of uric acid by regulating the expression of urate transporter.Here we reviewed the experimental research on pharmacological effect of anti-hyperuricemic natural products,expounding the pharmacological mechanism of treating hyperuricemia with the ingredients or the effective parts of natural products,providing reference for the study on anti-hyperuricemic new drugs and Chinese medicine treatment of gout.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2015年第8期1483-1486,共4页
Natural Product Research and Development
基金
国家自然科学基金(30960476)
云南省自然科学基金(2011FZ262)
云南省教育厅科学研究基金(2012J016)
关键词
高尿酸血症
天然产物
药理作用
研究进展
hyperuricemia
natural products
pharmacological activity
research progress
