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慢性肾脏病胰岛素抵抗发生的分子机制及干预研究 被引量：9

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摘要 慢性肾脏病（chronic kidney disease,CKD）的防治是近年来世界范围内重要的公共卫生问题,各国对其投入逐渐增加[1]。CKD患者肾功能多随时间缓慢恶化,最终将发展至终末期肾脏病（end stage of renal disease,ESRD）。上世纪八十年代,DeFronzo等[2]的研究首次发现维持性血液透析患者存在胰岛素抵抗（insulin resistance,IR）现象。
作者 杨悦 魏日胞
机构地区 中国人民解放军总医院肾脏病科 南开大学医学院
出处 《中国中西医结合肾病杂志》 2015年第7期642-644,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
基金 国家自然科学基金资助项目(No.81273968 81471027) 民政部老龄委基金资助项目(No.QLB2014W002) 301百项优势项目(No.YS201408)
关键词 胰岛素抵抗 慢性肾脏病 分子机制 维持性血液透析患者 干预 公共卫生问题 终末期肾脏病 世界范围
分类号 R692 [医药卫生—泌尿科学]
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参考文献30

  • 1National Kidney F. K/DOQI clinical practice guidelines for chro- nic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis,2002,39(2 Suppl 1) :S1 -266.
  • 2DeFronzo RA, Smith D, Alvestrand A. Insulin action in uremia. Kidney Int Suppl, 1983,16 : S102 - S114.
  • 3杨悦,魏日胞,王远大,邱强,荣娜,陈香美.223例慢性肾脏病患者胰岛素抵抗及其相关因素的研究[J].中华临床医师杂志（电子版）,2012,6(9):96-99. 被引量：8
  • 4Yang Y, Wei RB, Wang YD, et al. Higher HOMA - IR index and correlated factors of insulin resistance in patients with IgA ne- phropathy. Clinical Nephrology,2012,78 (5) :363 - 368.
  • 5Go AS, Chertow GM, Fan D, et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med,2004,351 ( 13 ) : 1296 - 1305.
  • 6DeFronzo RA, Ferrannini E, Sato Y, et al. Synergistic interaction between exercise and insulin on peripheral glucose uptake. J Clin Invest, 1981,68 (6) : 1468 - 1474.
  • 7Lizcano JM, Alessi DR. The insulin signalling pathway. Curr Bi- ol,2002,12(7) :R236 - R238.
  • 8Olivares - Reyes JA, Arellano - Plancarte A, Castillo - Heman- dez JR. Angiotensin II and the development of insulin resist- ance: implications for diabetes. Mol Cell Endocrinol, 2009,302 (2) :128 - 139.
  • 9Menon V, Rudym D, Chandra P, et al. Inflammation, oxidative stress,and insulin resistance in polycystic kidney disease. Clin J Am Soc Nephrol,2011,6( 1 ) :7 - 13.
  • 10Gao Z, Zuberi A, Quon M J, et 81. Aspirin inhibits serine phos- phorylation of insulin receptor substrate 1 in tumor necrosis fac- tor- treated cells through targeting multiple serine kinases. J Biol Chem ,2003,278 ( 27 ) :24944 - 24950.

二级参考文献12

  • 1张家庆.新的HOMA-IR——从空腹血糖、空腹胰岛素测胰岛素抵抗[J].中华糖尿病杂志（1006-6187）,2005,13(4):245-246. 被引量：54
  • 2Piotr W, Marek S, Zbigniew N, et al. Insulin resistance as a noveltherapeutic target in patients with chronic kidney disease treated with dialysis. Pol Arch Med Wewn,2010,120:54-57.
  • 3Kobayashi S, Maesato K, Moriya I-I, et aI. Insulin resistance in patients with chronic kidney disease. Am J Kidney Dis,2005,45:275-280.
  • 4Kobayashi S,Maejuma S,Ikeda T,et al. Impact of dialysis therapy on insulin resistance in end-stage renal disease : comparison of haemodial- ysis and continuous ambulatory peritoneal dialysis. Nephrol Dial Transpl,2000,15 : 65 -70.
  • 5Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA model- ing. Diabetes Care ,2004,27 : 1487-1495.
  • 6/danley AJG, Williams K, Stern MP, et al. Homeostasis model assess- ment of insulin resistance in relation to the incidence of cardiovascular disease--The San Antonio Heart Study. Diabetes Care ,2002,25:1177- 1184.
  • 7Ikee R, Hamasaki Y, Oka M, et al. Glucose metabolism, insulin resist- ance,and renal pathology in non-diabetic chronic kidney disease. Nephron Clin Pract ,2008,108 : C163-C168.
  • 8Sarafidis PA, Ruilope LM. Insulin resistance, hyperinsulinemia, and renal injury: mechanisms and implications. Am J Nephrol, 2006,26 : 232 -244.
  • 9Yudkin JS. Insulin resistance and the metabolic syndrome-or the pit- falls of epidemiology. Diabetologia,2007,50 : 1576-1586.
  • 10Samocha-Bonet D, Chisholm DJ ,Tonks K, et al. Insulin-sensitive obe- sity in humans--a" favorable fat" phenotype? Trends Endocrine Met, 2012,23 : 116-124.

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中国中西医结合肾病杂志
2015年 第7期

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