摘要
目的:探讨阻塞性睡眠呼吸暂停综合征(OSAHS)与椎动脉狭窄、血浆内皮素-1(ET-1)之间的关系。方法:选择经多导睡眠监测仪检测,睡眠呼吸暂停低通气指数(AHI)≥5次/h的104例OSAHS患者与AHI<5次/h的47例正常对照组患者作为研究对象,彩超检测患者椎动脉病变,酶联免疫反应测定血浆ET-1水平。结果:OSAHS组患者椎动脉狭窄发生率、斑块形成率明显高于对照组,分别为(29.8%vs12.8%)、(26.9%vs 10.6%),差异有统计学意义(P<0.05)。AHI与椎动脉V1、V2段平均血管内径(Vd)呈负相关(r=-0.31,P<0.05),与血浆ET-1水平无显著相关(P>0.05)。夜间最低动脉血氧(LSa O2)与Vd呈正相关,(r=0.36),与ET-1呈负相关(r=-0.41),均P<0.05。结论:OSAHS患者椎动脉狭窄、粥样硬化斑块发生率增高;反复呼吸暂停、夜间缺氧引起血浆ET-1升高可导致椎动脉损伤。
Objective： To investigate the correlation of obstructive sleep apnea-hypopnea syndrome（ OSAHS） with vertebral artery stenosis and plasma endothelin-1（ ET-1）. Methods： Determined by polysomnographic monitor,104 OSAHS patients whose apnea-hypopnea index（ AHI） ≥ 5 times / h（ OSAHS group） and 47 patients whose AHI5times / h（ normal control group） were included as the subjects in the study.Color Doppler ultrasound was used to examine vertebral artery lesions. Plasma ET-1 level was measured by enzyme-linked immunosorbent assay（ ELISA）. Results： The incidence of vertebral artery stenosis and plaque formation in OSAHS group were significantly higher than those in the control group（ 29.8% vs. 12.8%,26.9% vs.10.6%）,with statistically significant differences（ P 0. 05）. AHI was negatively correlated with mean vessel diameter in V1 and V2 segments（ r =-0. 31,P 0. 05）. No significant correlation was found between AHI and plasma ET-1 level. The night-time lowest arterial oxygen saturation（ LSa O2） was positively correlated with Vd and negatively correlated with ET-1（ r = 0. 36,r =-0. 41,all P 0. 05）. Conclusion： The occurrence of vertebral artery stenosis and atherosclerotic plaque increase in OSAHS patients. Increased plasma ET-1 induced by recurrent apnea and night-time hypoxemia may lead to vertebral artery lesions.
出处
《广州医科大学学报》
2015年第3期57-60,共4页
Academic Journal of Guangzhou Medical University
