摘要
目的:观察综合消化道毒物清除术在重度有机磷农药中毒(AOPP)中的临床效果。方法:重度AOPP患者56例随机分为2组,对照组给予常规洗胃、阿托品、抗感染、吸氧等综合治疗,观察组在对照组基础上行综合消化道毒物清除术,对2组治疗一般情况、血清学指标和转归结果进行比较。结果:观察组患者的住院时间、住院费用、清洁肠道时间、阿托品用量、氯磷定用量、阿托品化时间和胆碱酯酶恢复正常时间均明显少于对照组(P<0.01)。治疗后2组患者的白细胞、肌酸激酶、乳酸脱氢酶、天冬氨酸氨基转移酶、血清抵抗素和内脂素水平较治疗前显著降低(P<0.01);且观察组患者白细胞、肌酸激酶、乳酸脱氢酶、天冬氨酸氨基转移酶、血清抵抗素和内脂素水平均较对照组显著降低(P<0.01)。观察组患者病死率显著低于对照组(P<0.01);观察组的严重并发症发生率显著低于对照组(P<0.01)。结论:综合消化道毒物清除术可清除毒物,恢复胆碱酯酶水平,提高治愈率,减少并发症,在重度AOPP治疗中值得应用。
Objective： To observe the clinical effects of the application of comprehensive digestive tract poison removal in patients with severe organophosphorus pesticide poisoning（ AOPP）. Methods： Fifty-six severe AOPP patients were randomly divided into the control group and observation group. The control group and observation group were treated with the conventional gastric lavage,atropine,antiinfection and oxygen therapy,and comprehensive digestive tract poison removal based on the control group,respectively. The general condition,serological indexes and outcome between two groups were compared. Results： The hospitalization time,hospitalization cost,cleaning intestinal time,atropine dosage,pralidoxime chloride dosage,atropinization time and cholinesterase recovery time in observation group were significantly less than those in control group（ P〈0. 01）. After treatment,the levels of the white blood cells,creatine kinase,lactate dehydrogenase,aspartate transaminase,serum resistin and visfatin in two groups decreased significantly（ P〈0. 01）,and the decreasing degree of whose in observation group were significantly higher than those in control group（ P〈0. 01）. The mortality and incidence of severe complications in observation group were significantly lower than those in control group（ P〈0. 01）. Conclusions：The comprehensive digestive tract poison removal can clean poison,recover cholinesterase level,improve cure rate and reduce complications,which is worthy of clinical use during the treatment of severe AOPP.
出处
《蚌埠医学院学报》
CAS
2015年第8期1008-1011,共4页
Journal of Bengbu Medical College
关键词
农药中毒
有机磷农药
消化道
毒物清除术
pesticide poisoning
organophosphorus pesticide
digestive tract
poison removal
