摘要
目的探讨多囊卵巢综合征（polycystic ovarian syndrome,PCOS）患者代谢综合征（metabolic syndrome,MS）及其各组分的发病情况,评估MS各组分对预测PCOS患者合并MS的预测能力。方法选取2013年12月至2014年7月就诊于首都医科大学附属北京妇产医院内分泌科被确诊为多囊卵巢综合征患者180例,所有患者均收集人体测量学指标、基础内分泌指标和血糖血脂等生物化学指标,评估PCOS患者MS及其各组分的发病情况,筛选对PCOS患者发生MS高风险的预测指标。结果 ① 180例PCOS患者MS的患病率为43.89%;②不同年龄段的患病率分别为17-24岁32.14%、25-29岁39.53%、30-34岁50%、35-39岁80%;正常体质量、超质量、肥胖、重度肥胖的患病率非别为10.00%、51.16%、69.57%、85.71%;③合并有MS的PCOS患者的年龄和体质量指数均高于非MS的PCOS患者（29.16±3.85 vs 27.47±3.81,P=0.004;31.44±4.89 vs 24.29±4.87,P=0.000）,两组患者的血总睾酮浓度差异无统计学意义（P〈0.05）;④ PCOS患者发生MS最好的预测指标是高密度脂蛋白胆固醇〈1.29 mmol/L（敏感度为91.14%,特异度为88.12%）。结论 PCOS患者是发生代谢综合征的高风险人群,年龄和肥胖情况是决定不同人群代谢综合征患病率的关键因素。通过高密度脂蛋白胆固醇水平可以较好的评估PCOS患者发生代谢综合征的风险。
Objective To investigate the prevalence of metabolic syndrome（MS） and its components in women with polycystic ovary syndrome（PCOS）, and analyze the ability of MS components to predict MS risk in PCOS patients. Methods A total of 180 women with PCOS participated in this study between December 2015 and July 2014. All of the subjects were examined for anthropometric, serum hormone level and biochemical parameters. We investigated the incidence of MS and its components, screening predictors for PCOS patients at high risk of MS. Results The prevalence of MS in PCOS patients was 43.89%. The prevalence in different age groups was 32.14% for 17-24 years, 39.53% for 25-29 years, 50.00% for 30-34 years and 80.00% for 35-39 years. The prevalence in different BMI groups was 10.00% for normal, 51.16% for overweight, 69.57% for obese and 85.71% for morbidly obese women. The age and BMI in PCOS patients with MS were higher than those of patients without MS（29.16±3.85 vs 27.47±3.81, P=0. 004 ; 31.44±4.89 vs 24.29±4.87, P= 0. 000, respectively）, the total testosterone level in two group was similar（P〈0.05 ）. The best predictors of metabolic syndrome in PCOS was HDL-C〈1. 29 mmol/L（ sensitivity 91.14% and specificity 88.12% ）. Conclusion Women with PCOS have high risk for MS, age and the degree of obesity could be the main determinants of the prevalence of metabolic syndrome in different populations. The level of HDL-cholesterol could be a good predictor of the risk of MS in PCOS patients.
出处
《首都医科大学学报》
CAS
北大核心
2015年第4期553-558,共6页
Journal of Capital Medical University
基金
国家外国专家局2015年度北京市引进国外技术
管理人才项目(GDJ20151100013)
北京市卫生系统高层次卫生技术人才(2014-2-016)
首都医科大学附属北京妇产医院
北京妇幼保健院学科带头人项目(2013-1)~~
