转录因子7类似物2基因多态性与新疆维吾尔族人群2型糖尿病遗传易感性的关系被引量：4

Relationship between genetic polymorphism of transcription factor 7-like 2 and genetic susceptibility to type 2 diabetes mellitus in Uygur population of Xinjiang region

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摘要目的探讨新疆地区维吾尔族人群转录因子7类似物2(TCF7L2)基因多态性与2型糖尿病的关系。方法采用病例-对照研究设计,以经确诊的819例2型糖尿病患者作为病例组,选取731例健康个体作为对照组。收集研究对象血液标本5m L,提取基因组DNA。应用基质辅助激光解吸附电离飞行时间质谱分析质谱技术(MALDI-TOF)进行多态性检测,用logistic回归计算OR(95%CI)值,比较不同基因型与2型糖尿病患病风险的关系。结果病例组TCF7L2基因rs7901695位点的TC和CC基因型频率,C等位基因频率显著高于对照组(P<0.05)。未发现TCF7L2基因与环境因素的交互作用与2型糖尿病相关联。结论 TCF7L2基因rs7901695多态性位点可能与新疆维吾尔族人群2型糖尿病具有相关性,而rs7085532多态性位点可能与新疆维吾尔族人群2型糖尿病无相关性。 Objective To identify the potential association of transcription factor 7-like 2 （ TCF7L2 polymorphisms with type 2 diabetes mellitus in Uygur population of Xinjiang region. Methods In this case-control study,819 ca- ses of type 2 diabetes mellitus patients were recruited in case group and 731 healthy individuals were selected as control. 5 mL of blood sample were collected from each subject. The polymorphism was examined by matrix-assis- ted laser desorption/ionization-time of flight （MALDI-TOF） and the OR value （95% CI） was evaluated by Logistic Regression Method to analyze the relationship between susceptibility to type 2 diabetes mellitus and different geno- types. Results In case group, the frequencies of TC, CC genotype and C allele at rs7901695 were higher than the corresponding frequencies in control group （P 〈 0. 05）. The interaction between TCF7L2 and environment risk factors did not contribute to the occurrence of the type 2 diabetes mellitus. Conclusions The polymorphisms of rs7091695 in TCFTL2 but not rs7085532 in TCG7L2 may be associated with type 2 diabetes mellitus in Uygur pop-ulation in Xinjiang region.

作者王志强马琦王婷婷苏银霞马艳朱筠姚华

机构地区新疆医科大学公共卫生学院新疆医科大学第一附属医院代谢性疾病重点实验室

出处《基础医学与临床》 CSCD 2015年第9期1162-1166,共5页 Basic and Clinical Medicine

基金国家重点基础研究发展计划(973计划)(2012CB722403)

关键词多态性 TCF7L2基因 2型糖尿病维吾尔族 polymorphisms TCFTL2 gene type2 diabetes meUitus Uygur

分类号 R587.1 [医药卫生—内分泌]

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