摘要
目的检测卵巢良性肿瘤患者血清中抗苗勒管激素（AMH）及抑制素B（INHB）的表达,评估良性卵巢肿瘤患者的卵巢储备功能。方法选取卵巢良性肿瘤需行手术治疗的患者90例,其中卵巢子宫内膜异位囊肿组60例（观察组）,卵巢囊肿组30例（对照组）。90例患者按年龄段分成4组（25～岁组、31～岁组、36～岁组、41～45岁组）,采用ELISA法分别检测上述患者术前血清中AMH、INHB表达水平。结果卵巢良性肿瘤患者血清中AMH、INHB的表达与年龄呈负相关,差异有统计学意义（P〈0.05）;双侧卵巢子宫内膜异位囊肿患者血清中AMH及INHB的表低于单侧卵巢子宫内膜异位囊肿患者,差异无统计学意义（P〉0.05）。卵巢良性肿瘤患者血清中AMH和INHB呈明显正相关性（P〈0.05）。结论 AMH和INHB均与年龄密切相关,单一AMH和INHB变化均可预测不同年龄段、良性卵巢肿瘤患者卵巢的储备功能;良性卵巢肿瘤患者血清AMH和INHB表达呈正相关且与不同病理类型、双侧是否受累有关。
Objective To evaluation of ovarian reserve function by the methods to investigate the expression of AMH and INHB in peripheral blood serum of the patients with benign gynecological tumors. Methods A prospective analysis was performed on 90 patients,60 cases with endometriosis（experimental group） and 30 cases with ovarian cyst（control group）,which was divided into four layers according to age,ELISA method was used to measure the expression of the AMH and INHB in peripheral blood serum. Results The level of serum AMH and INHB in different age groups was significantly different（P〈0. 05）. The level of AMH and INHB in patients serum with ovarian endometriosis cysts were significantly lower than that in the control group at the same age layers. The ovarian reserve function of the patients with endometriosis was worse than patients in control group. Conclusion The detection of AMH and INHB is sensitive in predicting the ovarian reserve function. The AMH and INHB levels in serum have positive correlation with ovarian function.
出处
《宁夏医学杂志》
CAS
2015年第9期795-797,共3页
Ningxia Medical Journal
