摘要
Stem cells are pluripotent cells, having a property of differentiating into various types of cells of human body. Several studies have developed mesenchymal stem cells(MSCs) from various human tissues,peripheral blood and body fluids. These cells are then characterized by cellular and molecular markers to understand their specific phenotypes. Dental pulp stem cells(DPSCs) are having a MSCs phenotype and they are differentiated into neuron, cardiomyocytes, chondrocytes, osteoblasts, liver cells and β cells of islet of pancreas. Thus, DPSCs have shown great potentiality to use in regenerative medicine for treatment of various human diseases including dental related problems. These cells can also be developed into induced pluripotent stem cells by incorporation of pluripotency markers and use for regenerative therapies of various diseases. The DPSCs are derived from various dental tissues such as human exfoliated deciduous teeth, apical papilla, periodontal ligament and dental follicle tissue. This review will overview the information about isolation, cellular and molecular characterization and differentiation of DPSCs into various types of human cells and thus these cells have important applications in regenerative therapies for various diseases. This review will be most useful for postgraduate dental students as well as scientists working in the field of oral pathology and oral medicine.
Stem cells are pluripotent cells, having a property ofdifferentiating into various types of cells of humanbody. Several studies have developed mesenchymalstem cells （MSCs） from various human tissues,peripheral blood and body fluids. These cells are thencharacterized by cellular and molecular markers tounderstand their specific phenotypes. Dental pulpstem cells （DPSCs） are having a MSCs phenotype andthey are differentiated into neuron, cardiomyocytes,chondrocytes, osteoblasts, liver cells and β cells of isletof pancreas. Thus, DPSCs have shown great potentialityto use in regenerative medicine for treatment of varioushuman diseases including dental related problems.These cells can also be developed into induced pluripotentstem cells by incorporation of pluripotencymarkers and use for regenerative therapies of variousdiseases. The DPSCs are derived from various dentaltissues such as human exfoliated deciduous teeth,apical papilla, periodontal ligament and dental follicletissue. This review will overview the information aboutisolation, cellular and molecular characterization anddifferentiation of DPSCs into various types of humancells and thus these cells have important applications inregenerative therapies for various diseases. This reviewwill be most useful for postgraduate dental students aswell as scientists working in the field of oral pathologyand oral medicine.
基金
Supported by Jaslok Hospital and Research Centre,Mumbai,India,Project ni491,A/C 27814
