摘要
目的：分析和探讨重组人脑钠肽对心肌梗死所致急性心力衰竭的疗效和肾功能的影响。方法选择在漯河市中心医院进行治疗的心肌梗死所致急性心力衰竭患者60例，随机将其分为观察组和对照组，每组30例，对照组给予常规、纠正心力衰竭以及硝酸甘油治疗，观察组则在常规治疗和纠正心力衰竭治疗的基础上给予重组人脑利钠肽（rhBNP）注射治疗，治疗结束后对两组患者的心功能指标、心力衰竭症状缓解情况进行比较，并检测血浆脑钠肽、尿素氮、血肌酐浓度和24 h 尿量。结果观察组和对照组治疗总有效率分别为96．7%和73．3%，观察组显著高于对照组，差异有统计学意义（P 〈0.05）；与对照组相比，观察组尿素氮和血肌酐均有轻度增加，血钾浓度轻度降低，差异未见统计学意义（P 〉0.05）。结论心肌梗死所致急性心力衰竭采用重组人脑钠肽进行治疗能够有效提高疗效，并且不会影响患者的肾功能，建议在临床上推广应用。
Objective To analyze and investigate the effect of recombinant human brain natriuretic peptide on the efficacy and renal function of acute heart failure caused by myocardial infarction. Methods Sixty patients with acute heart failure caused by myocardial infarction in the central hospital of Luohe were selected and divided into the observation group and the control group,with 30 cases in each group. The patients in the control group were given routine treatment, correcting heart failure treatment and nitroglycerin treatment; and the patients in the observation group were given rhBNP injection in addition. Heart function indexes and remission of the symptoms of heart failure of two groups were compared after treat-ment, plasma brain natriuretic peptide,urea nitrogen, concentration of serum creatinine,24 h urinary volume were checked. Results In the observation group and the control group, the total effective rate was 96. 7% and 73. 3% , that in the observation group was significantly higher than that in the control group（P 〈 0. 05）. Compared with the control group, the levels of urea nitrogen and creatinine in the observation group slightly increased, blood potassium concentration slightly decreased, the differences were not signifi-cant（P 〉 0. 05）. Conclusions Acute heart failure caused by myocardial infarction with recombinant human brain natri-uretic peptide can effectively improve the curative effect, and has no effect on the patient’s renal function, so it is recom-mended in clinical application.
出处
《中国实用医刊》
2015年第19期36-38,共3页
Chinese Journal of Practical Medicine
关键词
心肌梗死
急性心力衰竭
重组人脑钠肽
疗效
肾功能
Myocardial infarction
Acute heart failure
Brain natriuretic peptide
Curative effect
Renal function
