摘要
目的探讨沙格列汀对糖尿病前期人群的干预效果。方法收集符合流行病筛查标准的糖尿病前期患者298例,其中空腹血糖受损组84例,糖耐量异常组126例,糖化血红蛋白异常组88例,将每组患者随机分为治疗组和对照组两个亚组。治疗组在对生活方式进行干预的同时给予沙格列汀治疗,对照组仅给予生活方式的干预。随访18个月后比较治疗效果。结果 18个月后,三组患者的治疗组在体重指数、腰臀比、血糖、糖化血红蛋白、空腹胰岛素和餐后2小时胰岛素指标的改善优于相应对照组(P<0.05)。结论沙格列汀对糖尿病前期人群的血糖及体重水平具有较好的干预效果,可改善其血糖及控制体重。
Objective To investigate the intervention effect of saxagliptin for the pre-diabetes.Method data of 298 cases which are in consistent with the epidemiological screening criteria of pre-diabetes were collected, including 84 cases of impaired fasting glucose, 126 cases of impaired glucose tolerance and 88 cases of abnormal hemoglobin. Each group was randomly divided into treatment group and control group. The treatment group received lifestyle intervention while giving saxagliptin treatment; the control group received only lifestyle intervention. The therapeutic effect was compared after 18-month follow-up.Result after 18 months, the indexes of Bmi、WHr、fBg、2hBg、Hba1c、fasting insulin and 2h postprandial insulin of the patients in the treatment group were significantly higher than those of the control group（P〈0.05）.Conclusion saxagliptin has better intervention effect for pre-diabetes on blood glucose and weight. it could improve the blood glucose and weight control.
出处
《创伤与急诊电子杂志》
2015年第3期26-29,共4页
Journal of Trauma and Emergency(Electronic Version)
