摘要
目的研究姜黄素缓释微丸的制备工艺和最优处方,并对体外释药机制进行探讨。方法利用挤出滚圆法制备姜素丸芯,单因素考察和正交设计筛选最优处方,并对最优处方进行包衣。通过体外释药实验探讨释药机制。结果采用挤出滚圆法制备的姜黄素缓释微丸外观圆整。筛选的最优处方姜黄素、卡波姆、乙基纤维素、硬脂酸、微晶纤维素的比例为5∶6∶5∶3∶50。包衣干燥的最佳工艺因素为60℃,24 h。包衣处方为100 g水分散体滑石粉用量为1 g,增塑剂PEG6000为2 g,包衣增重为10%。结论通过挤出滚圆方法制备的姜黄素丸芯外观圆整,收率高。缓释微丸12 h释药量达90.54%,释放曲线符合Weibull方程。
Objective To investigate the preparation technique and optimal formulation of Curcumin （Cur）in sustained - release mini - pill and the release mechanism of Cur from the mini - pill. Methods Cur sustained - release mini - pill was prepared by extrusion - spheronization method. Based on the studies of influential factors, optimal formulation modified to release drug was obtained by the orthogonal design. And release mechanism of Cur from Cur sustained - release mini - pill was established by equation fitting. Results Extrusion spheronization technology was used to prepared Cur sustained - release mini - pill. The proportion of curcumin, carbomer, ethyl cellulose, stearic acid, MCC is 5：6 ： 5 ： 3：50. The optimum coating technological factors is 60 ℃ , and 24 h. Coating prescription for 100 g some talcum powder dosage is 1 g,plasticizer PEG6000 as 2 g,coating weight gain of 10%. Conelusion By extruding rolling method of the preparation of curcumin pill core round appearance, high yield. Slow release micro pill 12 h release dosage of 90.54% ,conform to the Weibull release curve equation,the micro pill preparation technology is simple ,the quality controllable.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2015年第9期2140-2143,共4页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金(No.81303142)
高等学校博士学科点专项科研基金项目(No.20121210120001)
天津市应用基础与前沿技术研究计划(No.14JCQNJC13100)
天津市高等学校科技发展基金计划项目(No.20110215)
关键词
姜黄素
缓释微丸
制备工艺
处方优化
挤出滚圆
Curcumin
Sustained - release mini - pill
Preparation process
Prescription optimization
Extrusion - spheronization
