摘要
目的:探讨参麦注射液联合阿托伐他汀治疗急性心肌梗死临床疗效观察。方法:将符合标准的148例老年急性脑梗死患者随机分成观察组和对照组各74例,对照组给予阿托伐他汀治疗,观察组给予参麦注射液和阿托伐他汀联合治疗。观察两组患者血脂水平、血清生化指标、临床疗效以及不良反应。结果:治疗2个疗程后,观察组TC、TG、LDL-C、HDL-C及apo B水平较治疗前和对照组均显著下降(P<0.05),而apo A与Lp A水平较治疗前和对照组均显著上升(P<0.05),观察组血清hs-CRP、ET和MMP-9水平水平较治疗前和对照组均显著下降(P<0.05),观察组住院期间病死率、心衰发生率、休克发生率、再梗发生率显著低于对照组,而冠脉再通率显著高于对照组(P<0.05)。结论:参麦注射液联合阿托伐他汀治疗急性心肌梗死疗效肯定,值得临床推广。
Objective ：To integrative the clinical efficacy of Shenmai Injection and atorvastatin in treatment of patients with acute myocardial infarction. Methods： 148 patients with this disease were randomly divided into observation group 74 cases） and control group. （74 cases）. Patients in control group were treated with atorvastatin while others were treated with Shenmai Injection and atorvastatin. The blood lipid level, serum biochemical indexes, clinical curative effect and adverse reactions of patients in both groups were observed. Results ： After the treatment, the levels of TC, TG, LDL - C, HDL - C and apoB of patients in observation group were significantly lower than those of patients in control group （ P 〈 0.05 ） while the levels of apoA and LpA of patients in observation group were significantly higher than those of patients in control group （P 〈 0.05）. The levels of hs - CRP, ET and MMP - 9 of patients in observation group were significantly lower than those of patients in control group （P 〈 0.05 ）. The in - hospital mortality, the incidence of heart failure and shock incidence and rates of re - infarction of patients in observation group were significantly lower than those of patients in control group while coronary artery re -canalization rate of patients in observation group was significantly higher than that of patients in control group （P 〈 0.05）. Conclusion： The treatment of acute myocardial infarction with Shenmai Injection ：and atorvastatin has a curative effect and it is worthy of clinical promotion.
出处
《中华中医药学刊》
CAS
北大核心
2015年第10期2558-2560,共3页
Chinese Archives of Traditional Chinese Medicine
关键词
急性心肌梗死
参麦注射液
阿托伐他汀
Shenmai injection
acute myocardial infarction
atorvastatin
