摘要
目的:分析宫颈薄层液基细胞学(TCT)联合高危型人乳头状瘤病毒(高危型HPV)检测对筛查宫颈鳞状上皮内瘤变的应用价值。方法:2014年1月至12月选取2400例自愿接受宫颈病变筛查的妇女,均行TCT筛查。对218例TCT检查结果阳性者(ASCUS及以上)进一步行高危型HPV检测及阴道镜下宫颈活检病理检查。结果:在218例TCT检查结果阳性者中,TCT结果与病理学结果符合率分别为鳞状上皮低度病变(LSIL)60%,非典型鳞状细胞-不除外上皮内高度病变(ASC-H)84.6%,鳞状上皮高度病变(HSIL)100%。高危型HPV在不同程度的宫颈癌前病变中占的比例分别为CINⅠ87.8%、CINⅡ91.6%、CINⅢ93.3%,高危型HPV的感染率随着宫颈病变的严重程度增加而明显升高。TCT检查及高危型HPV检测阳性与病理学符合率为65.9%。结论:TCT联合高危型HPV检测提高了宫颈鳞状上皮内瘤变筛查的特异性及敏感性,具有良好的临床应用价值。
Objectives：To analyze the application value of ThinPrep cytology （TCT）in combination with high -risk type HPV testing for screening cervical intraepithelial neoplasia （CIN）.Methods：2400 women willing to receive cervical disease screening from January to December 201 4 were selected for TCT screening.21 8 women with positive screening results （ASCUS and above）were further given high risk HPV testing and colposcopy and bi-opsy.Results：Of the 21 8 women,the cytological and pathological diagnosis coincidence rate of LSIL,ASC -H and HSIL was 60%,84.6% and 1 00%.The positive rate of high -risk type HPV in different colposcopy and biop-sy lesions were CINⅠ of 87.8%,CINⅡ of 91 .6% and CINⅢ of 93.3%.The positive rate of high risk type HPV increased significantly with the aggravating degree of colposcopy and biopsy lesions.The consistency was 65.9% for pathology vs.HPV assay plus TCT positive.Conclusion：TCT combined with high -risk type HPV testing,increa-ses the sensitivity and specificity of the diagnosis of cervical lesions,having good clinical application value.
出处
《中国性科学》
2015年第8期24-26,共3页
Chinese Journal of Human Sexuality
