摘要
自噬是细胞维持物质和能量动态循环的一个复杂系统,是胞内组分运送至溶酶体降解的重要途径,并且受到胞内的细胞信号网络调控。自噬可以被不同类型的营养受限所诱导,并在细胞物质合成和降解、能量供应、细胞信号转导等方面发挥功能,这对于细胞的自我更新和内环境稳态具有重要意义。自噬的异常可能是导致许多疾病发生的关键因素,因此,对自噬内在特点和调控机制的研究将有助于探索新的疾病诊疗方法。
Autophagy is a complex system to maintain the dynamic cycles of matter and energy, and is an important way for the cytoplasmic components to be delivered to and degraded in the lysosome. Autophagy is regulated by the intracellular signaling networks and induced by different types of nutrient limitations, plays crucial role in the synthesis and degradation of cellular materials, energy supply and cell signaling, those are very important for the cell self renewal and homeostasis. Abnormalities of autophagy may be a key factor that contributes to the occurrence of many diseases. Therefore, the researches on the inherent characteristics and regulation mechanisms of autophagy will help to explore the new methods of diagnosis and treatment for the diseases.
出处
《解剖科学进展》
CAS
2015年第5期552-555,559,共5页
Progress of Anatomical Sciences
基金
国家自然科学基金资助项目(No.81401224)
