摘要
目的：探讨胃癌患者血清中热休克蛋白70（HSP70）和 p53的表达水平及其与幽门螺旋杆菌（H．pylori）的相关性。方法选择50例胃癌患者作为研究对象，其中Ⅰ～Ⅱ期30例，Ⅲ期20例；22例伴淋巴结转移，28例无淋巴结转移。选择40名健康者为健康对照组。检测受试者血清 HSP70、p53水平。结果胃癌组血清 HSP70、p53表达水平高于健康对照组，差异均有统计学意义（t ＝12．53、16．79，均 P ＜0.01），随着胃癌临床分期的增加，血清 HSP70、p53水平呈升高趋势（t ＝4．68、5．29，均 P ＜0．01）；同时，伴淋巴结转移的患者血清 HSP70、p53表达水平高于无淋巴结转移的患者，差异均有统计学意义（t ＝3．82、4．39，均 P ＜0．01）；胃癌组 H．pylori 阳性患者血清 HSP70、p53表达水平高于 H．pylori 阴性患者，差异均有统计学意义（t ＝4．72、4．17，均 P ＜0．01）。结论胃癌患者血清中 HSP70、p53表达明显增高，并且 HSP70、p53的表达与胃癌的进展、预后及 H．pylori 感染密切相关。
Objective To study the expression levels of serum HSP70 and p53 in gastric cancer and its cor-relation with helicobacter pylori infection.Methods 50 patients with gastric cancer were selected as the research object.Among 50 cases,30 cases were stage Ⅰ -Ⅱ,20 cases were stage Ⅲ,22 cases were with lymph node metasta-sis and 28 cases were without lymph node metastasis.40 healthy subjects were selected as the healthy control group. The serum levels of HSP70 and p53 were detected.Results In the gastric cancer group,the serum levels of HSP70 and p53 were markedly higher than those of the healthy control group,and the difference was statistically significant （t =12.53,16.79,all P 〈0.01）.Moreover,with progressing of clinical stage of gastric cancer,the serum levels of HSP70 and p53 showed a trend of increasing（t =4.68,5.29,all P 〈0.01）.The serum expression levels of HSP70 and p53 in gastric cancer with lymph node metastasis were significantly higher than those of patients without lymph node metastasis and the difference was still statistically significant（t =3.82,4.39,all P 〈0.01）.The serum levels of HSP70 and p53 in the gastric cancer group with Hp positive were much higher,compared to those of cases with Hp negative and the difference was also statistically significant（t =4.72,4.17,all P 〈0.01）.Conclusion In the gastric cancer patients,the serum expression level of HSP70 and p53 are increased.The expression of HSP70 and p53 are closely related to the progress and prognosis of gastric cancer and Hp infection.
出处
《中国基层医药》
CAS
2015年第18期2781-2783,共3页
Chinese Journal of Primary Medicine and Pharmacy
