摘要
目的:探讨鱼油脂肪乳对严重创伤病人血清炎性递质水平调节作用和预后的影响。方法:选择严重创伤病人(ISS评分>16分)40例,随机分为两组,A组为对照组,B组加用鱼油脂肪乳0.2 g/(kg·d)。两组病人均接受等氮、等热量的全胃肠外营养(TPN),并于治疗前和治疗后第3、5和7天分别检测两组病人的血清C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素-1(IL-1)和IL-6的水平。统计两组病人多器官功能障碍综合征(MODS)的发生率和28 d病死率。结果:B组病人治疗后不同时间点血清CRP、TNF-α、IL-1和IL-6均明显降低,与A组比差异有显著性统计学意义(P<0.05)。B组MODS发生率明显下降(P<0.05),28 d病死率有所降低,但无显著性差异。结论:鱼油脂肪乳可调节严重创伤病人炎性递质的释放,降低严重创伤病人血清CRP、TNF-α、IL-1和IL-6水平,能减少严重创伤病人MODS的发生率。
Objective ： To discuss the function of serum inflammatory mediators regulation of fish oil fat emulsion in patients with severe trauma and the prognosis. Methods： 40 patients （ISS score 〉 16 points） with severe trauma were selected and were randomly divided into A and B groups. The two group patients received equal nitrogen and total parenteral nutrition （TPN）, and group B patients were injected fish oil fat emulsion 0.2 g / （ kg · d）. C-reactive protein （ CRP）, tumor necrosis factor-or （TNF-α）, interleukin-1 （IL-1） and intedeukin-6 （IL-6） were detected before and after treatment, The incidence and the mortality of the multiple organ dysfunction syndrome （MODS） of the two group were observed respectively. Results ： In the group B the CRP, TNF-α, IL-1, IL-6 and the MODS incidence were significantly lower （P 〈 0.05 ）than that in the group A. Conclusion： Fish oil fat emulsion can modulate the release of inflammatory mediators in patients with severe trauma, reduce the level of CRP, TNF-α, IL-1, IL-6, and decrease occurrence MODS.
出处
《肠外与肠内营养》
CAS
北大核心
2015年第5期276-278,共3页
Parenteral & Enteral Nutrition
关键词
鱼油脂肪乳
创伤
炎性递质
预后
Fish oil fat emulsion
Trauma
Inflammatory mediators
Prognosis
