摘要
目的系统评价乳酸菌阴道胶囊降低外阴阴道念珠菌病(VVC)复发的疗效及安全性。方法计算机联机检索Cochrane图书馆、CNKI、VIP、万方数据库(各数据库检索时间为创建至2014年12月)中关于乳酸菌阴道胶囊降低VVC复发的随机对照试验(RCT),用RevMan 5.3软件对数据进行Meta分析。结果共纳入18篇RCT,包括2 450例患者。Meta分析结果显示,乳酸菌阴道胶囊降低VVC复发的效果优于对照组[RR=0.34,95%CI(0.28,0.41),P<0.000 01]。结论基于现有临床证据,乳酸菌阴道胶囊降低VVC复发有效,安全性高。但由于纳入研究数量较少,研究质量不统一,本结论尚需要更多大样本、高质量临床RCT予以证实。
Objective To systematically evaluate the efficacy and safety of Lacidophilin Vaginal Capsules in patients with Vulvovaginal candidiasis （VVC） in China. Methods The randomized controlled trials （RCTs） of Lacidophilin Vaginal Capsules for reducing VVC recurrence were searched by computer in the Cochrane Library, CNKI, VIP and WANFANG Database （from their inception to Decembe, 2014）. Meta analysis of the data was carried out by using RevMan 5.3 software. Results Eighteen RCTs were included with a total of 2,450 patients. The Meta analyses showed that the effects of Lacidophilin Vaginal Capsules to reduce VVCrecurrence were superior to those of the control group [RR=0.34, 95%CI （0.28, 0.41）, P〈 0. 000 011. Conclusion Based on the existing clinical evidences, the Lacidophilin Vaginal Capsules as an ad juvant therapy for VVC are effective and safe. Howerver, due to the small amount of included studies, this conclusion needs to be further identified by more and larger samples and high-quality RCTs.
出处
《中国微生态学杂志》
CAS
CSCD
2015年第10期1206-1209,共4页
Chinese Journal of Microecology
基金
成都市医学重点专科建设资助项目(成卫科教函〔2014〕2号)
