摘要
宫颈癌是病死率较高的妇科肿瘤之一,严重危害女性健康,因其有较长的癌前病变期,合理筛查便成为控制肿瘤发生、发展的关键。研究表明,宫颈细胞由非典型性发育异常向宫颈癌转变的过程中几乎都伴有人类染色体端粒酶(h TERC)基因的扩增,该基因扩增可阻止细胞凋亡,导致肿瘤发生。目前,利用荧光原位杂交技术(FISH)进行h TERC基因扩增检测已被用于宫颈病变的筛查。该文就h TERC基因检测对宫颈癌的诊断价值及FISH的检测优势予以综述。
Cervical cancer is one of the gynecological tumors,the fatality of which is high causing serious damage to women′s health. Reasonable screening has become the key to control the development of the tumor because of its longer precancerous period. Studies have showed almost all process from atypical dysplasia to cervical cancer is accompanied by amplification of human telomerase RNA component gene（ hTERC gene） , which can prevent apoptosis and lead to tumorigenesis. At present,detecting the amplification of hTERC gene by fluorescence in situ hybridization（ FISH） has been used in screening of cervical lesions. Here is to make a review about its progress and advantages.
出处
《医学综述》
2015年第19期3506-3508,共3页
Medical Recapitulate
基金
珠海市科技计划项目(2011B040102003)
