摘要
目的 探讨骨密度（BMD）和血钙、血磷、25（OH）维生素D3、碱性磷酸酶（ALP）、Ⅰ型前胶原氨基端伸展肽（PINP）、Ⅰ型胶原羧基末端肽（CTX）等指标在系统性红斑狼疮（SLE）继发骨量减少及骨质疏松中的临床价值。方法 通过测定SLE女性患者腰椎（L1~4）、两侧股骨颈BMD,从中筛选出40例继发骨量减少及骨质疏松患者,测定血钙、血磷、25（OH）维生素D3、ALP、PINP、CTX等指标,并与40例同年龄段健康女性各指标进行对比。结果 所选患者与同年龄段健康女性相比各部位BMD均显著降低（P〈0.001）。患者的25（OH）维生素D3水平较健康女性显著降低（P〈0.001）,而血钙、血磷、ALP、PINP、CTX等差异无统计学意义（P〉0.05）。结论 SLE继发骨量减少及骨质疏松患者的血清25（OH）维生素D3水平下降,血钙、血磷、ALP、PINP、CTX水平与BMD不存在显著相关性。
Objective To explore the clinical value of bone mineral density（ BMD） and serum calcium、serum phosphate、25（ OH） vitamin D3、alkaline phosphatase（ ALP） 、aminoterminal propeptide of type Ⅰ procollagen（ PINP）,type Ⅰ collagen carboxyl terminal peptide（ CTX） levels in patients with secondary osteopenia and osteoporosis due to systemic lupus erythematosus（ SLE）.Methods Forty patients with secondary osteopenia and osteoporosis by detecting SLE female patients＇ BMD of lumbar spine（ L1 ~ 4） and bilateral femoral neck were selected. Serum calcium、serum phosphate、25（ OH） vitamin D3,ALP,PINP,CTX were detected and compared with forty healthy women of the same age. Results Each part of BMD in patients were significantly lower than that in healthy women of the same age（ P 0. 001）. The 25（ OH） vitamin D3 level in patients were also significantly lower than healthy women of the same age（ P 0. 001）,but the serum calcium,serum phosphate,ALP,PINP,CTX level had no significant differences（ P 0. 05）. Conclusion The 25（ OH） vitamin D3 level decreases in patients with secondary osteopenia and osteoporosis due to SLE,and there is no significant correlation between the levels of serum calcium,serum phosphate,ALP,PINP,CTX and BMD.
出处
《实用临床医药杂志》
CAS
2015年第19期30-33,共4页
Journal of Clinical Medicine in Practice
关键词
骨密度
25(OH)维生素D3
I型前胶原氨基端伸展肽
I型胶原羧基末端肽
系统性红斑狼疮
bone mineral density
25（OH） vitamin D3
aminoterminal propeptide of type Ⅰ procollagen
type Ⅰ collagen carboxyl terminal peptide
systemic lupus erythematosus
