摘要
目的观察缬沙坦联合硝苯地平治疗原发性高血压的临床疗效。方法将符合纳入标准的100例原发性高血压患者根据治疗方法不同分为观察组(缬沙坦联合硝苯地平治疗)和对照组(硝苯地平治疗),每组各50例,疗程4周,4周后对两组的疗效进行评价,同时对两组患者治疗前后的SBP、DBP的变化情况进行对比分析。结果观察组的总有效率显著高于对照组(96%vs 76%,P<0.05)。观察组治疗4周后的收缩压、舒张压分别达(110.25±7.86)mm Hg、(81.31±6.23)mm Hg,对照组治疗4周后的收缩压、舒张压分别达(117.24±3.54)mm Hg、(86.31±5.12)mm Hg,差异有统计学意义(P<0.05)。结论缬沙坦、硝苯地平联合治疗原发性高血压可提高单纯应用硝苯地平治疗的疗效,显著降低血压水平,且不良反应少,安全性好,值得推广和应用。
Objective To observe the clinical effect of valsartan combined with nifedipine in treatment of primary hy- pertension. Methods All of 100 cases of primary hypertension patients according to the different treatment methods were randomly divided to observation group（valsartan and nifedipine treatment） and control group（nifedipine）, each with 50 cases,the course was 4 weeks,after treatment 4 weeks,the curative effect was evaluated,and changes of the SBP and DBP were compared and analyzed before and after treatment. Results The total efficiency in the observation group was significantly higher than that of the control group（96% vs 76%,P〈0.05）. After treatment 4 weeks, systolic blood pressure, diastolic blood pressure in observation group was（110.25±7.86） mmHg, （81.31±6.23） mmHg,the control group was （117.24±3.54） mm Hg, （86.31±5.12） mmHg respectively,the difference was significant between two groups （P〈0.05）. Conclusion Valsartan combined with nifedipine in treatment of primary hypertension can improve the cura- tive effect, reduce the level of blood pressure and adverse reactions less, the security is good, and it is worthy of pro- motion and application.
出处
《中国现代医生》
2015年第29期89-91,共3页
China Modern Doctor
关键词
原发性高血压
缬沙坦
硝苯地平
收缩压
舒张压
Hypertension
Valsartan
Nifedipine
Systolic blood pressure
Diastolic blood pressure
