摘要
抑郁症的确切病因及病理机制尚不清楚。近几年,越来越多的证据提示神经可塑性机制在抑郁症发病及治疗中的作用,其中神经营养因子在神经可塑性中发挥着极其重要的作用。Ras相关信号通路作为一条重要的神经营养因子受体下游信号通路在神经可塑性中发挥着重要的作用。该文对Ras信号通路与抑郁症神经可塑性机制的相关研究进行综述。
The pathogenesis of depression has not been clearly elucidated yet. In recent years, more and more evidences highlight the role of neural plasticity mechanism in the pathogenesis and treatment of depression. Particularly, neurotrophic factors are critical for the neural plasticity. Meanwhile the Ras signaling pathway, a vital downstream signaling pathway of the neurotrophic factor receptor, plays an important role in the neural plasticity. This paper reviews studies relevant to Ras signaling pathways and the neural plasticity mechanism of depression.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2015年第10期1556-1559,共4页
Journal of Shanghai Jiao tong University:Medical Science
基金
国家自然科学基金(91232719)
国家临床重点专科-上海市精神卫生中心(卫生部医政司2011-873)
科技部"十二五"国家科技支撑项目(2012BAI01B04)~~
